Abstract Details

Title Localized Gray Matter Changes in Acute Stroke

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P05 - (-)

Poster/Presentation
Number 244

Objective

Background BACKGROUND: Global grey matter volume decreases with age.There is also evidence that changes in sub-cortical gray matter volume is associated with cognitive impairment after stroke(3-6 months period).

Design/Methods DESIGN/METHODS: Patients with stroke(N=11, non-cortical ischemic stroke within 7 days of stroke onset, mean age 58,6M), patients with risk factors for stroke (N=5,mean age 69 ,3M) and age-matched healthy controls (N=17,mean age 56, 10 M) were scanned on a GE 3T MRI scanner. High-resolution 3D T1-weighted whole brain BRAVO FSPGR images were collected with: repetition time TR = 8.13 ms, echo time TE=3.18ms, flip angle=12,156 slices, voxel resolution 1 mm isotropic. The subjects performed a letter fluency task. Gray matter changes were assessed using VBM8 and SPM8 in Matlab.

Results RESULTS: There was a significant group difference between acute stroke patients and healthy controls on the verbal task(p<.05) with patients scoring less(mean score=35) than healthy controls(mean score= 49). Two sample t test indicated significant group differences between strokes and controls in gray matter volume in regions of bilateral inferior temporal, bilateral middle temporal, right post central (p<.001(uncorrected), extent threshold 20 voxels). Analysis with verbal fluency score as covariate identified differences in the left inferior temporal and left middle temporal regions (p<.001(unc), extent threshold 20 voxels).There were no significant differences between healthy controls and patients with risk factors.

Conclusions CONCLUSIONS: There are localized gray matter changes notably in the temporal lobe in acute period of stroke showing significant association with verbal fluency deficits in these patients. This suggests that acute stroke may induce regional changes in gray matter volume. This could be attributed to stroke as well as chronic changes due to risk factors for stroke. Further studies will test this.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
Matthew Jensen, MD (Concord Hospital)	No disclosure on file
Marcus Chacon, MD (University of Wisconsin Hospital)	No disclosure on file
Justin A. Sattin, MD (University of Wisconsin)	The institution of Dr. Sattin has received research support from NIH / NINDS.
Veena A. Nair, PhD (DEPT. OF RADIOLOGY , UW MADISON)	The institution of Dr. Nair has received research support from NIH.
Vivek Prabhakaran, MD (University of Wisconsin)	Dr. Prabhakaran has nothing to disclose.
Anthony Traboulsee, MD (University of British Columbia)	Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Traboulsee has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Traboulsee has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for EMD Serono. Dr. Traboulsee has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Roche. The institution of Dr. Traboulsee has received research support from Roche. The institution of Dr. Traboulsee has received research support from Consortium of MS Centers. The institution of Dr. Traboulsee has received research support from MS Canada. Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving as a Workshop Chair with Consortium of MS Centers.

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