Abstract Details

Title Plasma Homocysteine and C677T MTHFR Polymorphism but Not A1298C Polymorphism Are Associated with Ischemic Stroke but Not with Ischemic Heart Disease or Peripheral Vascular Disease in South Indian Tamilian Population

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P04 - (-)

Poster/Presentation
Number 054

Objective

Background BACKGROUND: Association of Ischemic stroke and other vascular diseases with plasma homocysteine levels and MTHFR polymorphisms vary in different populations. South Indian Tamilian population is deemed to have distinct genetic identity.

Design/Methods DESIGN/METHODS: Case-control design. The association of Plasma homocsyteine levels(micromoles/l) between ischemic stroke (N=126) and control groups (MI=71, PVD=22, non-vascular cerebraldisease=23,non-vascular healthy=75) groups were tested using analysis of variance. The comparison of frequencies and association with haplotypes involving C677T and A1296C allelic combinations were also tested between the groups. The observed and expected genotype frequencies compared to test for deviations from Hardy-Weinberg equilibrium.The odds ratios and 95% confidence intervals were calculated to estimate associations in comparison to MI, PVD, non-vascular brain diseases and also to non-vascular healthy controls under study for MTHFR gene polymorphisms.

Results RESULTS: Mean homocysteine levels were significantly (P,0.003) higher in stroke (14.5; SD 9.8)compared to non-stroke vascular controls (9.8;SD 5.7). MTHFR 677 CT and TT mutants were significantly (P,0.009) higher in stroke patients compared to pooled non-vascular controls. The OR for CT and TT allele groups for Stroke was 3.9 (CI, 1.5-9.8). There was no significant (P,0.194)difference between 1298 AA, AC and CC mutant ratios between the same subject groups. However for the CT/AC haplotype, the association was even higher for stroke against non-vascular group(OR 4.8, CI 1.2-23.6). There was no significant difference in homocysteine levels (P,0.8) between MI and non-vascular controls. For the PVD group too homocysteine levels or the MTHFR SNPs allele frequencies were not significantly different from the non-vascular control groups.

Conclusions CONCLUSIONS: There is significant association between ischemic stroke and plasma homocysteine and MTHFR C677T but not A1298C polymorphisms in South Indian Tamilian patients. No such association was seen for other vascular diseases.

Authors/Disclosures
Sunil K. Narayan, MD, FAAN (Jawaharlal Institute of Postgraduate Medl Edu and Research) PRESENTER	The institution of Dr. Narayan has received research support from Indian Council of Medical Research, Ministry of Health and Family Welfare, Government of India. The institution of Dr. Narayan has received research support from Department of Biotechnlogy, Ministry of Science and Technology, Government of India. The institution of Dr. Narayan has received research support from DST-(SERB). The institution of Dr. Narayan has received research support from Ms.Gurutva Medical Technology, India. Dr. Narayan has received intellectual property interests from a discovery or technology relating to health care. Dr. Narayan has received intellectual property interests from a discovery or technology relating to health care. Dr. Narayan has received personal compensation in the range of $0-$499 for serving as a Intermediate Grants, Evaluation Expert committee Member with Department of Health Research, Government of India.
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