Abstract Details

Title Extreme White Matter Hyperintensity Volumes Are More Prevalent in African Americans in a Cohort at Risk for Vascular Disease

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P05 - (-)

Poster/Presentation
Number 232

Objective

Background BACKGROUND: Because stroke rates are higher in African American (AA) populations, we hypothesized that signs of small vessel cerebrovascular disease would also be greater in the subcortical brain region in healthy high risk people. Our objective was to examine the relationship between AA race and increased subcortical (SC) ischemic white matter hyperintensity (WMH) volume, in an apparently healthy population at increased risk for vascular disease.

Design/Methods DESIGN/METHODS: We imaged the brains of subjects who were first or second degree relatives of probands with early onset coronary disease prior to 60 years of age. WMHs were manually delineated on 3T cranial MRI by a trained radiology reader the location and volume of lesions were characterized using automated software. SC data was characterized as being in the upper 25% versus lower 75% of total SC lesion volume. WMH volume in the upper quartile vs. the remainder were examined for AA versus European American (EA) race using multiple logistic regression (GEE adjusted for family relatedness) and adjusted for major vascular disease risk factors including age ? 55 years, sex, current smoking , obesity, hypertension, diabetes , and LDL>160.

Results RESULTS: Subjects (n=593) were all healthy with no clinical vascular disease; 58% women, 37% AA, with a mean age of 51.5±11, and range of 29-74 years. AA race was significantly, independently associated with total SC WMH lesion volume in the upper 25%, OR = 1.77, (95% CI 1.14 to 2.74) (P=0.01).

Conclusions CONCLUSIONS: This study shows that AA is independently associated with an extreme of SC WMH lesion burden. Our findings suggest that early subclinical small vessel disease may be more prevalent in AA at high risk for stroke because of family history.

Authors/Disclosures
Paul A. Nyquist, MD, MPH, FAAN (johns hopkins) PRESENTER	Dr. Nyquist has received personal compensation in the range of $500-$4,999 for serving as a Consultant for astra Zenneca. The institution of Dr. Nyquist has received research support from NIH.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Rebecca F. Gottesman, MD, PhD (Johns Hopkins University)	The institution of Dr. Gottesman has received research support from NIH.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Diana Beccari	No disclosure on file

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