Abstract Details

Title Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort

Topic Aging and Dementia

Presentation(s) P07 - (-)

Poster/Presentation
Number 150

Objective

Background BACKGROUND: Previous studies utilizing neuropsychological assessments to differentiate clinically-diagnosed SIVD versus AD have demonstrated greater impairment in executive function and better preservation of recognition memory in SIVD. Because cognitive performance may influence clinical diagnosis, we compared neuropsychological profiles of SIVD and AD in cases defined by neuropathological criteria.

Design/Methods DESIGN/METHODS: Subjects in the Ischemic Vascular Dementia Program Project had been followed longitudinally and came to autopsy. We identified 20 SIVD cases defined by a high infarct score (CVD-PS ?20) and low Braak & Braak Score (B&B ? 3) and 70 AD cases defined by (CVD-PS < 20) and (B&B ? 4). Baseline neuropsychological tests, including MAS word list learning test, FAS, and animal fluency, were compared between the two autopsy-defined groups.

Results RESULTS: The SIVD and AD groups did not differ by age, education, or MMSE. Subjects with AD performed worse on delayed recall (mean total recall SIVD = 43.1 ±14.4; AD= 32.9 ±14.3; p<0.006). There was a trend showing greater impairment in category versus phonemic fluency in AD (AD category minus phonemic fluency = 1.7 ±6.6; SIVD = 4.7 ±4.6 vs,p = 0 .06).

Conclusions CONCLUSIONS: In neuropathologically-defined subgroups, neuropsychological profiles distinguish patients with AD from those with SIVD. The pattern of deficits in AD is consistent with medial and lateral temporal lobe dysfunction, while the pattern in SIVD is consistent with impairment in frontal executive function.

Authors/Disclosures
Liliana A. Ramirez-Gomez, MD, FAAN (Wang Ambulatory Care Center) PRESENTER	The institution of Dr. Ramirez-Gomez has received research support from NIA-NIH.
Craig McDonald, MD (UC Davis Dept. of PM&R)	Dr. McDonald has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Sarepta Therapeutics. Dr. McDonald has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for PTC Therapeutics. Dr. McDonald has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Solid Biosciences. Dr. McDonald has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. McDonald has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sarepta Therapeutics. Dr. McDonald has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Solid Biosciences. Dr. McDonald has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Edgewise Therapeutics. The institution of Dr. McDonald has received research support from Sarepta Therapeutics. The institution of Dr. McDonald has received research support from PTC Therapeutics. The institution of Dr. McDonald has received research support from Edgewise Therapeutics. The institution of Dr. McDonald has received research support from Capricor Therapeutics. The institution of Dr. McDonald has received research support from Italfarmaco. Dr. McDonald has received research support from NS Pharma. The institution of Dr. McDonald has received research support from NIH (NINDS). The institution of Dr. McDonald has received research support from Parent Project Muscular Dystrophy. The institution of Dr. McDonald has received research support from Muscular Dystrophy Association. Dr. McDonald has received personal compensation in the range of $500-$4,999 for serving as a Member National Advisory Board for Medical Rehabilitation Research with NIH.
Ling Zheng, MBBS, PhD (University of Southern California)	No disclosure on file
Bruce R. Reed, PhD (UC Davis Alzheimer's Disease Ctr)	No disclosure on file
Harry Vinters	No disclosure on file
Joel Kramer, PhD (UCSF Medical Center)	The institution of Dr. Kramer has received research support from tau consortium. Dr. Kramer has received publishing royalties from a publication relating to health care.
	No disclosure on file
Helena C. Chui, MD (University of Southern California)	The institution of Dr. Chui has received research support from National Institute on Aging .

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