Abstract Details

Title Circadian Sleep Rhythm in Patients with Drug-Refractory Epilepsy: A Case Control Study

Topic Sleep

Presentation(s) P05 - (-)

Poster/Presentation
Number 018

Objective

Background BACKGROUND: Most work on circadian sleep rhythms and epilepsy has focused on the impact of sleep wake cycles on seizure occurrence and generalization. There is little literature on the impact of epilepsy on the circadian sleep wake cycles. Identification of abnormalities in these cycles among patients with refractory epilepsy could have important management implications.

Design/Methods DESIGN/METHODS: Consecutive patients with drug-refractory epilepsy were studied clinically and with 7 days of continuous wrist actigraphy, sleep-logs and sleep quality questionnaires and each was compared with his/her own sibling with similar evaluation. Paired't' test was employed as test of significance.

Results RESULTS: Ten patients (8males; mean age 21.4 + 6.8yrs) were compared with 10 controls (8 males; mean age 23.2+6.9yrs) . The average number of naps among cases were 2.7+ 2.4 and average time spent during naps was 5.2+ 4.38 hrs whereas in controls mean no of naps were 1.9+ 1.72 and average time spent during naps was 2.5+ 2.1 hrs, per 24 hours. Average wake time during nights, was 79.44+ 42.3 minutes among cases and 56.11+ 17.20 min in controls. Sleep efficiency was 77.4+ 8.3% in cases and 82+3.3% in controls. No statistical difference was observed for most parameters analyzed, however, there was a clear trend towards difference in sleep efficiency as well as total naptime per 24 hours.

Conclusions CONCLUSIONS: Circadian sleep cycles among patients with drug-refractory epilepsy are not significantly different from their siblings. Actigraphically computed sleep efficiency was found low among patients as well as siblings, much worse in the former.

Authors/Disclosures
Ankit Singhal, MD, MBBS (COSMOS HOSPITAL) PRESENTER	No disclosure on file
Kailash P. Bhatia, MD, FAAN (UCL)	Dr. Bhatia has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ipsen. Dr. Bhatia has received publishing royalties from a publication relating to health care.
	No disclosure on file
Deepti Vibha, MD (All India Institute of Medical Sciences)	Dr. Vibha has nothing to disclose.
	No disclosure on file
Madhuri Behari, MD (All India Institute of Medical Science)	No disclosure on file
Achal K. Srivastava, MD, FAAN (AIIMS)	Dr. Srivastava has nothing to disclose.

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