Abstract Details

Title A Two Fold Higher Rate of Fatal Intraventricular Hemorrhages in African American Infants in United States

Topic Child Neurology/Developmental Neurobiology

Presentation(s) P03 - (-)

Poster/Presentation
Number 002

Objective

Background BACKGROUND: Despite recognition of racial/ethnic differences in pre-term gestation, the racial/ethnic differences in the rate of intraventricular hemorrhage (IVH), frequently associated with pre-term gestation, are not well studied.

Design/Methods DESIGN/METHODS: We identified all mortalities related to IVH using the ICD-10 code P52.0, P52.1, P52.2, P52.3 and P10.2 that occurred in infants aged less than 1 year from the Multiple Cause of Death data files from 2000 to 2009. The live births for whites and African Americans from the population census of 2000-2009 were used to derive the incidence of fatal IVH for whites and African Americans per 100,000 live births. We also calculated the IVH rate ratio [RR] (95% confidence interval [CI]) and percent change (APC) in incidence rates from 2000-2009.

Results RESULTS: A total of 3,249 fatal IVHs cases were reported during 2000 to 2009. The incidence rates of IVH were higher among African Americans infants (16 per 100,000) than in whites (7.8 per 100,000). African Americans infants had a 2 fold increased risk of fatal IVH compared with whites (RR, 2.0; 95% CI, 1.2-3.2). The rate of increase over the last 10 years was less in African American infants (APC, 1.6%) compared with change in incidence during the same time period for white infants (APC, 4.3%).

Conclusions CONCLUSIONS: The rate of fatal IVH is twofold higher among African American infants compared with white infants. Further studies are required to understand the underlying reasons for this prominent disparity in one of the most important causes of infant mortality.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
Shahram Majidi, MD (Icahn School of Medicine at Mount Sinai)	Dr. Majidi has nothing to disclose.
Hamza I. Maqsood, MD (Dept of Neurology)	Dr. Qureshi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for AstraZeneca.
Werner Poewe, MD (University Hospital of Neurology)	Werner Poewe, MD has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Affiris . Werner Poewe, MD has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alterity, AbbVie, BIAL, Biogen, Britannia, Lilly, Lundbeck, Neuroderm, Neurocrine, Denali Pharmaceuticals, ,Roche, Takeda, UCB and Zambon . Werner Poewe, MD has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for AbbVie, Britannia, BIAL, STADA, Lundbeck, Zambon. The institution of Werner Poewe, MD has received research support from MJFF; EU Horizon programme. Werner Poewe, MD has a non-compensated relationship as a Committee member with Movement Disorder Society that is relevant to AAN interests or activities.

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