Abstract Details

Title Vitamin D Deficiency and Osteoporosis in Stroke Survivors: An Analysis of National Health and Nutritional Examination Survey (NHANES) 2001-2006

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P04 - (-)

Poster/Presentation
Number 080

Objective

Background BACKGROUND: Vitamin D deficiency might be involved in the development of several diseases including hypertension, diabetes mellitus and cardiovascular disease. An inverse association between 25(OH) D levels and stroke was emphasized in recent studies.

Design/Methods DESIGN/METHODS: Participants from the National Health and Nutritional Examination Survey (NHANES) from 2001 through 2006 were included. Serum 25(OH) D levels were measured using the DiaSorin RIA kit (Stillwater MN) and history of previous stroke and osteoporosis was ascertained by standard interview. Stroke survivors were then divided into 2 groups depending on serum 25(OH) D levels: <30ng/dL as vitamin D deficiency and ?30ng/dL as normal. Demographics and risk factors comparisons between two groups were performed using the SAS software. Multivariate analysis was performed to determine the association between vitamin D deficiency and osteopororis in stroke survivors after adjusting for potential confounding factors.

Results RESULTS: There were 415 (4.0%) stroke survivors among the total 10,255 participants in NHANES. The stroke survivors mean age [±SD] was 67.56 [±17.3] years and 211 (50.8%) were men. Mean 25(OH) D concentrations were found to be not different significantly in patients with stroke (20.35 versus 21.82ng/mL, p=0.657) although the rate of osteoporosis was significantly higher among stroke survivors (17.92% versus 6.99%, p<0.0001). Out of 415 stroke patients, vitamin D deficiency was seen in 71.0% of the patients (mean concentration of 17.3±6.4ng/dL) and was normal in 29.0% patients (mean concentration of 34.6±5.3ng/dL). The rates of osteoporosis were similar between patients with or without Vitamin D deficiency. After adjusting for potential confounders, there was no association between vitamin D deficiency and osteoporosis.

Conclusions CONCLUSIONS: Vitamin D deficiency and osteoporosis are highly prevalent among stroke survivors, however, there does not appear to be a relationship between the two entities.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Basit Rahim, MD (Virginia Commonwealth University Health System)	No disclosure on file
	No disclosure on file
	No disclosure on file
Anna Schubart (Novartis Institutes of BioMedical Research)	No disclosure on file
Hamza I. Maqsood, MD (Dept of Neurology)	Dr. Qureshi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for AstraZeneca.

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