Abstract Details

Title Distribution and Severity of Weakness in Patients with Polymyositis and Dermatomyositis: Different Pathophysiology, Different Affected Muscle Groups

Topic Muscle Disease/Neuromuscular Junction

Presentation(s) P07 - (-)

Poster/Presentation
Number 040

Objective

Background BACKGROUND: Polymyositis and dermatomyositis are both rare acquired inflammatory myopathies, presenting with similar features, such as subacute onset, proximal, symmetric muscle weakness and elevated serum CK levels. Despite these similarities, the two diseases have different immunopathological mechanisms.

Design/Methods DESIGN/METHODS: Clinical and laboratory findings of 48 patients diagnosed with dermtomyositis or polimyositis according to the Peter and Bohan criteria at the Department of Neurology, Istanbul Faculty of Medicine between 1992 and 2012 were retrospectively evaluated. SPSS version 13 was used for statistical analysis.

Results RESULTS: Twenty-five patients were diagnosed with PM and 23 with DM. Thirty patient were female. The mean age of onset was 40±15.4 years (ranging between 17 and 73 years). All of our patients had symmetrical proximal dominant weakness. Swallowing difficulties were more frequent in PM as compared to DM (p=0.03). PM patients had more profound weakness at the point of the maximum disease severity (p<0.001). Neck flexors, deltoid, pectoralis major, triceps, iliopsoas muscles, hip adductors and flexors were more severely affected in PM (p=0.002, p=0.013, p=0.028, p=0.008, p=0.002, p=0.002, p=0.002, respectively). The only two muscles which were more markedly affected in DM than PM were wrist extensors and hamstrings (p=0.002 and p=0.03).

Conclusions CONCLUSIONS: Our results suggest that detailed manual muscle testing may help in the differential diagnosis of PM and DM.

Authors/Disclosures
Hacer Durmus, MD (Department of Neurology, Istanbul Faculty of Medicine) PRESENTER	Dr. Durmus has nothing to disclose.
Feza Deymeer, MD (Memorial Sisli Hospital)	No disclosure on file
	No disclosure on file
Piraye Serdaroglu, MD (Istanbul University School of Medicine)	No disclosure on file
	No disclosure on file

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