Abstract Details

Title Assessment of Clinical Status of Patients with Multiple System Atrophy Using a Novel System To Evaluate the Dynamic Cerebellar Motor Learning Capability

Topic Movement Disorders

Presentation(s) P07 - (-)

Poster/Presentation
Number 204

Objective

Background BACKGROUND: We have recently developed a novel system to evaluate cerebellar functions based on the cerebellar motor learning capability (Hashimoto Y. et al. submitted under a separate abstract to this meeting). With this system, the cerebellar function appear faithfully reflected in an index that control individuals with normal cerebellar functions show values ranging between 0.5 and 1 (the maximum normal value), whereas individuals with cerebellar cortical degeneration show indexes below 0.5.

Design/Methods DESIGN/METHODS: To clarify whether testing the cerebellar motor learning is useful for the clinical assessment of patients with MSA, we investigated 9 patients with MSA comprising four of each probable MSA-C and MSA-P (Gilman S. et al, Neurology 2008; 71: 670-6).

Results RESULTS: We found that all MSA patients show abnormal values ranging between 0.032 and 0.48. In addition, there was a tendency that MSA-P patients show larger indexes ranging between 0.24 and 0.48 correlated with milder cerebellar dysfunctions. In contrast, subjects with severe cerebellar phenotypes demonstrated worse indexes ranging between 0.032 and 0.24. There was a tendency that the present index shows some correlation with disease duration, or with the severity of cerebellar ataxia assessed with SARA. However, such tendencies did not reach statistical significance possibly due to a small number of patients studied.

Conclusions CONCLUSIONS: We conclude that the present system could be a powerful tool to evaluate clinical severity of MSA patients irrespective of the clinical subtypes. Further investigation recruiting larger number of patients is currently underway.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Hidehiro Mizusawa, MD, PhD (National Center of Neurology and Psychiatry)	No disclosure on file
Kinya Ishikawa, MD, PhD (Tokyo Med & Dental Univ)	Dr. Ishikawa has nothing to disclose.
Volker Limmroth, MD, PhD (City of Cologne / Cologne General Hospital (Merheim))	No disclosure on file

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