Abstract Details

Title Temporal and Spacial Parameters of Gait Elucidate Abnormalities of Walking at Different Levels of EDSS

Topic MS and Related Diseases

Presentation(s) P04 - (-)

Poster/Presentation
Number 101

Objective

Background BACKGROUND: Gait is a complex function. Abnormalities of gait in patients with multiple sclerosis result from changes in muscle strength, spasticity, cerebellar symptoms and sensory tracts. Existing evaluation of gait in clinical practice is limited to EDSS and a measurement of the speed of walking. These measures do not reveal information about the changes in mechanism of the gait in patients with MS.

Design/Methods DESIGN/METHODS: 280 patients with multiple sclerosis representing EDSS levels of 0 to 6.5 were recruited from the outpatient MS clinic. Patients were examined by a neurologists to determine EDSS and tested for temporal and spacial characteristic of walking using an instrument GAITrite. Gait pattern was evaluated during a self selected speed and as fast as you can speed of walking.

Results RESULTS: The results of the study confirmed our hypothesis that temporal and spacial characteristics of gait closely correlate with EDSS scores in patients with EDSS 3.5 and higher. Pacients with higher EDSS score spend more time in a double support time in both self selected speed and fast speed of walking. Patient with multiple sclerosis have significantly decreased ability to increase the speed of gait, which is apparent even at lower EDSS levels.

Conclusions CONCLUSIONS: Temporal and spacial characteristics of gait inform us of the changes in gait mechanics at different levels of disability due to MS.

Authors/Disclosures
Jana Preiningerova, MD PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Evzen Ruzicka, MD, PhD (Movement Disorder Center)	No disclosure on file
Eva Havrdova, MD (Neurologicka Klinika 1 LF UK)	Dr. Havrdova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Havrdova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi. Dr. Havrdova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Havrdova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Havrdova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Havrdova has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Dr. Havrdova has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi.
	No disclosure on file

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