Abstract Details

Title Executive Dysfunction in the FTD Spectrum

Topic Aging and Dementia

Presentation(s) P03 - (-)

Poster/Presentation
Number 087

Objective

Background BACKGROUND: The FTD spectrum features at least three main, distinct clinical variants: behavioral variant FTD (bv-FTD), temporal variant FTD (tv-FTD): semantic dementia (SD) and progresive non-fluent aphasia (PNFA), as well as a motor variant (mv-FTD): progressive supranuclear palsy (PSP), amyotrophic lateral sclerosis (ALS) and corticobasal dementia (CBD). Executive dysfunction is one aspect of growing recognition for the diagnosis and treatment of patients with pathologies of the FTD spectrum. However, its assessment in daily clinical practice is still very limited.

Design/Methods DESIGN/METHODS: The INECO Frontal Screening (IFS) and the Addenbrook's cognitive examination (ACE) were apllied to 48 patients with bv-FTD, 47 patients with tv-FTD (23 patients with PNFA and 21 patients with SD), 7 patients with PSP, 16 patients with ALS and 9 patients with CBD. IFS scores were compared across groups and with a healthy control group (n = 28).

Results RESULTS: IFS total scores differed between the groups, with controls exhibiting significantly higher scores than all dementia groups, except for patients with ALS, who performed at at intermediate level between controls and the rest of the clinical groups. With a cut-off score of 25/30, sensitivity to detect any dementia within the FTD spectrum was 100% and specificity was 90%. The same sensitivity and specificity was found for the ACE-R with a cut-off score of 89/100. In all cases, the IFS demonstrated superior discriminatory accuracy to detect specific types of FTD spectrum dementias.

Conclusions CONCLUSIONS: The IFS is a brief screening tool for bedside assessment of executive functions. Because this cognitive domain appears to be primarily affected in FTD spectrum dementias, the IFS constitutes a valuable tool to contribute to the detection of FTD dementias in the early stages.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Facundo Manes	No disclosure on file
	No disclosure on file
	No disclosure on file

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