Abstract Details Title Bruxism Associated with Restless Limbs Syndrome (RLS): A Dopamine Responsive Movement Disorder Topic Movement Disorders Presentation(s) P02 - (-) Poster/Presentation Number 063 Objective Background BACKGROUND: Bruxism is a common movement disorder, of unknown etiology, affecting 10% of the population. Bruxism causes insomnia, TMJ, and dental and periodontal morbidity. Treatments with Occlusal Splints do not stop bruxism or reduce dental complications. No pharmacological treatments are currently available. Others have suggested an association of RLS and bruxism in population surveys. Bruxism and PLMS, seen in 80% of patients with RLS, occur in light, non-REM sleep. To our knowledge there has not been a study of RLS patients to determine if bruxism is associated and if it responds to therapies for RLS. Design/Methods DESIGN/METHODS: Patients who met the IRLSSG criteria for RLS completed a 35 question survey which investigated demographics, symptoms, associated conditions, family history and response to therapy. Charts were reviewed and interviews conducted to complete and clarify the data. The group presented here is part of an ongoing study of RLS and associated conditions. Results RESULTS: 312 RLS patients completed data collection. 127(40.7%) acknowledged history of bruxism. 48 of 127(38%) responded to DAs for their limb symptoms. Excluding non-respondents (ie: patients who did not receive treatment or could not recall their response),48 of 54 patients (85.7%) had improved bruxism when treated with DAs for RLS. Conclusions CONCLUSIONS: These data support a strong association between RLS and bruxism, both movement disorders and parasomnias, and suggests that bruxism, in this population, may respond to treatment with DAs. Although retrospective, non-controlled, and unblinded, this study should enhance disease appreciation and encourage a blinded and placebo-controlled trial of DA for bruxism associated with RLS. Finally, the data suggest that bruxism may be a manifestation of RLS and is a dopamine-responsive movement disorder that should be well-known to, and treated by, neurologists in the future. Authors/Disclosures David J. Dickoff, MD PRESENTER No disclosure on file No disclosure on file