Abstract Details

Title Correlation between Nerve Conduction Study and CSF Protein Level in Acute and Chronic Demyelinating Polyradiculopathies

Topic Clinical Neurophysiology

Presentation(s) P02 - (-)

Poster/Presentation
Number 233

Objective

Background BACKGROUND: Level of protein concentration in cerebrospinal fluid (CSF) might be elevated in immune-mediated polyradiculopathies as a result of the damage of myelin sheath. Guillain Barre syndrome (GBS) as an example for acute form, chronic inflammatory demyelinating polyradiculopathy (CIDP) as an example for chronic form have been enrolled to the study.

Design/Methods DESIGN/METHODS: We reviewed the findings of CIDP and GBS cases who had complet CSF and electrophysiological studies. The presence of axonal injury were excluded from the study. CSF and electrophysiological findings of GBS patients within the first 48 hours were obtained. Regardless of the disease duration, CIDP patients within a week were included to the study.

Results RESULTS: Twelve CIDP (mean age:59±15 years, female/male ratio: 5/7) and 10 GBS (mean age: 36±16 years, female/male: 6/4) cases were evaluated. Mean level of CSF protein in GBS was 323 ± 56 mg/dl and 49 ± 30 mg/dl in CIDP. There was significant positive correlation between elevated CSF protein in GBS and median-ulnar motor nerve distal latencies and median nerve F latency. Elevated CSF protein level in CIDP was also positively correlated with median, ulnar, peroneal and tibial motor nerve distal latencies but negatively correlated with median motor nerve amplitude and median, ulnar, tibial motor nerve conduction velocities.

Conclusions CONCLUSIONS: Our results showed significant correlation between elevated CSF protein level and all extremity motor nerves damage in CIDP but only upper extremity motor nerves damage in GBS. This situation might be originated from ascending progression of GBS. Also, elevated protein levels associated with nerve involvement of both upper and lower extremities might be originated from the chronic nature of CIDP. Further studies containing more than markers are needed.

Authors/Disclosures
Nilgun Cinar PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Sibel Karsidag	No disclosure on file
Kyra J. Becker, MD	No disclosure on file

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