Abstract Details

Title Glioblastoma Treatment in Elderly Patients: A Single Institution Experience between 2004 and 2011

Topic Neuro-oncology

Presentation(s) P01 - (-)

Poster/Presentation
Number 104

Objective

Background Elderly people represent a growing population, with its specific aspects and the fact that for high grade glioma, there is still no optimal treatment defined for them.

Design/Methods We treated 92 patients, 37 males and 55 females aged 70 to 88 years, for newly diagnosed glioblastoma, between January 2004 and December 2011. Treatment options were evaluated depending on age, Karnofsky Performance Status score, comorbidities and tumour characteristics. Data was retrospectively reviewed and follow-up ranged from 1 to 24 months.

Results Accessing treatment, 64 (69.6%) patients underwent a surgical procedure: 9 biopsies, 33 partial resections and 22 gross-total resections. Twenty-eight (30.4%) patients did not undergo surgery, so for them the diagnosis of high-grade glioma was neuroradiological. All patients underwent chemotherapy and 39 underwent additional radiation therapy. Median overall survival for the whole cohort was 301 days, 337 days for patients who underwent tumour resection, 238 days for patients with neuroradiological diagnosis of high-grade glioma. For the whole cohort, statistical study showed that surgery and radiation therapy conferred significant improvement in progression-free and overall survivals. Multivariate analysis revealed that only radiation therapy was the only variable remaining significant for longer progression-free and overall survivals.

Conclusions Outcomes in elderly patients with proved glioblastoma are really improved by surgery, followed by chemoradiation if their clinical status allows it. And for patients with comorbidities or bad tumour location, we propose chemotherapy by temozolomide without histopathological proof if we have MRI or CT scan strong positive arguments for a high-grade glioma.

Authors/Disclosures
PRESENTER	No disclosure on file
Philippe Alla	No disclosure on file
Alasdair Coles, MD, PhD (University of Cambridge)	Dr. Coles has nothing to disclose.

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