Abstract Details

Title Neural Correlates of Visual Hallucinations in Lewy Body Disease

Topic Aging and Dementia

Presentation(s) P04 - (-)

Poster/Presentation
Number 223

Objective

Background BACKGROUND: Visual hallucinations (VH) are one of the commonest feature in Lewy body disease (DLB) but they are still misunderstood. The aim of this study was to investigate the association between hallucinations in DLB and brain perfusion on single photon emission tomography (SPECT).

Design/Methods DESIGN/METHODS: Sixty-four patients with DLB were included and divided into two groups : patients with VH (DLB-hallu) and patients without VH (DLB-c).They were matched for age, sex and MMSE. A SPECT was done for each patient and compared between two groups according to the voxel based morphometry method. We also performed voxel-level correlations between perfusion and hallucination severity.

Results RESULTS: We found a significant decrease in perfusion in left anterior cingulate cortex (ACC) and in left occipital cortex (cuneus) in DLB-hallu group compared with DLB-c group. There was also a significant correlation between decreased right ACC perfusion and severity of hallucinations.

Conclusions CONCLUSIONS: VH seems associated with hypoperfusion in visual associative areas (bottom-up mechanism) and in anterior cerebral regions, as anterior cingulate gyrus, which is involved in error detection and decision-making (top-down mechanism). Right ACC hypoperfusion correlated with symptom severity, implicating right ACC in inhibitory control processes related to visual hallucinations.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
Nathalie Philippi (University Hospital of Strasbourg)	No disclosure on file
Benjamin Cretin, MD	No disclosure on file
	No disclosure on file
	No disclosure on file
Laurent D. Kremer	Laurent D. Kremer has nothing to disclose.
	No disclosure on file
Frederic Blanc (Hopital Service de Neurologie)	No disclosure on file
Michael A. Panzara, MD, MPH (Neurvati Neurosciences)	Dr. Panzara has received personal compensation for serving as an employee of Neurvati Neurosciences. Dr. Panzara has received personal compensation for serving as an employee of GRIN Therapeutics. Dr. Panzara has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Wave Life Sciences. Dr. Panzara has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Athira Pharma. Dr. Panzara has stock in GRIN Therapeutics. Dr. Panzara has stock in Cadenza Bio. Dr. Panzara has stock in Athira Pharma. Dr. Panzara has stock in Wave Life Sciences. Dr. Panzara has stock in Sanofi.

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