Abstract Details

Title Frontal vs Temporal Lobe Epilepsy: Personality Traits and Neuropsychological Profile

Topic Epilepsy

Presentation(s) P03 - (-)

Poster/Presentation
Number 139

Objective

Background BACKGROUND: Personality traits and depressive symptoms have been described in epileptic patients, mostly in temporal lobe epilepsy (Gastaut-Geschwind syndrom). Lately it has been found specific cognitive impairments.

Design/Methods DESIGN/METHODS: 26 patients aged 18 years or older (12 with FLE and 14 with TLE) matched by age and educational level with 21 healthy controls were studied with Bear Fedio personality Inventory , Depression Inventory in Epilepsy (NDDI-E), an extensive neuropsychological assessment (Trial Making Test, digit span, digit-symbol subtest Wais III, Signoret memory battery, Boston naming test, Semantic Fluency, Stroop test and Letter-Number Test- Wais III).

Results RESULTS: ELF present more traits of circumstantiality, religiosity and dependency, while patients with TLE present vital sadness, irritability, aggressiveness, hyposexuality, guilt, obsessionalism, circumstantialities, viscosity, self appreciation, dependency and sobriety than healthy controls. In between groups comparison, ELF patients differed significantly from TLE patients in aggression, guilt, obsessionalism, circumstantiality, viscosity, religiosity and sobriety. At the neuropsychological assessment we found that patients with ELF and ELT have significant deficit in language, executive functions, attention, verbal and visual memory compared with controls. Finally 27% of ELF patients suffered depression (NDDI-E >15), compared with 14% TLE patients and 6% of healthy controls.

Conclusions CONCLUSIONS: To define neuropsychological characteristics, depressive symptoms and personality traits allows a comprehensive approach to epileptic patient.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
Mauricio F. Farez, MD (FLENI)	Dr. Farez has received personal compensation for serving as an employee of Entelai. Dr. Farez has stock in Entelai. The institution of Dr. Farez has received research support from Fundación Sadosky.
Ugur Uygunoglu (Cerrahpasa)	Ugur Uygunoglu has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche Turkey . The institution of Ugur Uygunoglu has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. The institution of Ugur Uygunoglu has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen Idec/Gen Pharma of Turkey. The institution of Ugur Uygunoglu has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck-Serono of Turkey. The institution of Ugur Uygunoglu has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanovel of Turkey. The institution of Ugur Uygunoglu has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Genveon of Turkey.
Ricardo F. Allegri, MD, PhD, FAAN (Institute for Neurological Research (FLENI))	Dr. Allegri has nothing to disclose.

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