Abstract Details

Title West Nile Virus Neuroinvasive Disease: The Saskatchewan Experience

Topic Infections/AIDS/Prion Disease

Presentation(s) P04 - (-)

Poster/Presentation
Number 001

Objective

Background BACKGROUND: West Nile (WN) virus is an arthropod-borne virus of the family Flaviviridae. The main route of human infection is through the bite of an infected mosquito. Approximately 80% of West Nile Virus infections in human remain asymptomatic, but neuroinvasive disease occurs in less than 1% of infected individuals, and can be severe or even fatal.

Design/Methods DESIGN/METHODS: This study reviews the clinical profile of cases with West Nile neuroinvasive disease (WNND) reported by the Surveillance program of the Saskatoon Health Region in 2007. A total of 357 cases were reported. Neuroinvasive disease was defined by positive serology plus CNS symptoms using the standard criteria provided by the Public Health Agency of Canada.

Results RESULTS: 57 cases fulfilled the criteria for WNND. Mean age was 55 + 15.7. Thirty nine (68%) were female. 9 (16%) patients reported camping prior to symptoms. The most frequent symptoms were: 44 (77%) fever, 35 (61%) shivers, 31 (54%) nausea, 25 (43.9%)headache. The most common neurological manifestations were: confusion in 24 (42%), meningitis 23 (40.4%), encephalitis 17 (29.8%), encephalopathy 14 (24.6%), meningoencephalitis 11 (19.3%), tremor 10 (17.5%), acute flaccid paralysis 10 (17.5%), myoclonus 1 (1.8%), nystagmus 2 (3.5%), diplopia 2(3.5%), dizziness 2(3.5%). Three patients died (5%). CSF, and imaging findings will be discussed.

Conclusions CONCLUSIONS: During a year of high incidence of disease in Saskatchewan, 16% of cases developed West Nile neuroinvasive disease, but the outcome can be severe and persistent. Establishing the epidemiology and risk factors of neuroinvasive disease will be helpful in developing preventative strategies.

Authors/Disclosures
Edris Haghir, MD PRESENTER	No disclosure on file
Jose F. Tellez Zenteno, MD, PhD, FRCP	No disclosure on file
Gary Hunter, MD (Royal University Hospital)	No disclosure on file
Tuyen Ong	No disclosure on file

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