Abstract Details

Title Cardiac Death vs Stroke in Takayasu Arteritis. Long-Term Clinical Follow-Up

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P04 - (-)

Poster/Presentation
Number 045

Objective

Background BACKGROUND: TA is a rare chronic inflammatory disease involving the aorta (Ao) and its principal branches. The aim of this study was to evaluate the clinical evolution in special incidence of cardiac death and stroke in a long-term follow up.

Design/Methods DESIGN/METHODS: A retrospective review of 87 TA patients complying with the American College of Rheumatology (ACR) criteria. Cardiac and neurological follow-up was performed systematic every 6 months during fifteen years (1997-2012), incidental events were evaluated in the Emergency Department. Stroke-related to revascularization or endovascular procedures were excluded. Sonography, angiography, brain CT scan and MRI-angiography of aorta and supra-aortic arteries, cardiac catheterization was performed in all patients with cardiac symptoms. Coronary artery disease, steno-occlusive arterial lesions and the stroke/death were evaluated. Statistics evaluations: actuarial table analysis at 3, 5, 10 and 15 years, Kaplan Meier methods applying t function for probability. Mortality predictors: number of arterial lesions, time progression, anterior or posterior vascular involvement. Subtype of TA, cardiovascular involvement.

Results RESULTS: A total of 42 patients, 38 females, 4 men, mean age 38 ± 5 years at the time diagnosis, HBP was present in 28 (66.6%) patients,7 patients (16.6 %) had stroke, all of them in the Types I, IIa, IIb and V according to the panaortogram findings. Five patients died related to heart attack. High incidence of stroke occur during the 10-15 years of the AT evolution. Territory involvement: carotid territory 5 cases and 2 vertebrobasilar. Cardiovascular and HBP were impact in the mortality and risk of stroke.

Conclusions CONCLUSIONS: Coronary heart disease is a common cause of dead in TA, stroke exhibits low incidence in our population.

Authors/Disclosures
Aurelio Mendez-Dominguez, MD (Instituto Nacional De Cardiologia Ignacio Chavez) PRESENTER	Dr. Mendez-Dominguez has nothing to disclose.
	No disclosure on file
	No disclosure on file
Gary W. Small, MD (UCLA Semel Institute)	No disclosure on file

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