Abstract Details

Title Risk Factor Prevalence in a Young Stroke Population: Get with the Guidelines

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P03 - (-)

Poster/Presentation
Number 155

Objective

Background BACKGROUND: Stroke incidence has declined in the elderly, but had been increasing in young populations. It is unclear whether this is due to an increase in risk factor prevalence at a younger age than previously observed.

Design/Methods DESIGN/METHODS: Utilizing the Get-With-The-Guidelines-Stroke prospective database, we reviewed all cases of IS admitted to Boston Medical Center from January/08 -June/12. To better define the risk profile of our young population, we compared baseline social (racial,insurance), clinical (age, HTN, DM, dyslipidemia, smoking and CAD), stroke severity (based on admission NIHSS), and ambulatory status at discharge (independent /use of minimal assistance vs. unable to ambulate) between patients <40 vs 40-50years of age.

Results RESULTS: Among 1031 IS,158 (16%) were <50years, of whom 56 were <40years old (mean age 33, 52%M) and 102 were 40-50years old (mean age 46, 61%M). Among 158, 48% were Black, 33%White, 5%other and 14%undetermined. Most patients were Medicaid (48.8%) insured. Overall prevalence of all risk factors was high (57%HTN, 24%DM, 21%dyslipidemia, 12%CAD and 28%smoking). Older young patients (40-50years) compared to <40 group, were more likely to have HTN (p=0.003), DM (p<0.001), dyslipidemia (p=0.041), and CAD (<0.001).The mean NIHSS on admission was similar for both groups (5.1 in <40 vs.4.5). We observed a nonsignificant trend towards older young adults to be less frequently ambulatory at discharge. There was no significant difference between groups based on age, gender, race, insurance or smoking status.

Conclusions CONCLUSIONS: Our data suggest a high prevalence of stroke risk factors in a young population. More importantly, we observed a significantly increased prevalence of HTN, DM and dyslipidemia in patients 40-50years of age. Our findings suggest a need for more aggressive screening for primary stroke prevention at younger ages than previously recommended.

Authors/Disclosures
Aleksandra Pikula, MD PRESENTER	The institution of Dr. Pikula has received research support from CIHR.
	No disclosure on file
	No disclosure on file
Helena W. Lau	No disclosure on file
Jose R. Romero, MD (Boston University School of Medicine - Boston Medical Center)	The institution of Dr. Romero has received research support from NIH/NIA.
Thanh Nguyen, MD	Dr. Nguyen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Vesalio. Dr. Nguyen has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NIH. Dr. Nguyen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Avania. Dr. Nguyen has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for AHA. The institution of Dr. Nguyen has received research support from Boston Medical Center. The institution of Dr. Nguyen has received research support from Society of Vascular and Interventional Neurology.
Viken L. Babikian, MD, FAAN	Dr. Babikian has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boston Scientific. Dr. Babikian has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Baim Institute for Clinical Research. Dr. Babikian has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Boston Scientific.
Carlos S. Kase, MD, FAHA, FAAN	Dr. Kase has nothing to disclose.

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