好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Different Patterns of Gray and White Matter Atrophy in Patients with Asymptomatic Carotid Stenosis
Cerebrovascular Disease and Interventional Neurology
P07 - (-)
226
BACKGROUND: Subjects with asymptomatic carotid stenosis (ACS) presented in prior studies cognitive dysfuntion when compared to subjects without stenosis.
DESIGN/METHODS: Twenty-five patients (8 women, mean age of 68 years) with unilateral ACS (>70%) or occlusion, defined by computer tomography angiography, underwent 3T MRI. Images were analyzed with voxel based morphometry (VBM) and diffusion tensor imaging (DTI). We obtained 3D sagittal T1-weighted (voxel size 1x1x1 mm,TR = 22 ms, TE = 9 ms, flip angle = 35[deg], matrix = 256x220) for VBM and DTI images (TR=8500, TE=61, 2mm, 32 directions, b-value=1000). Images of patients with left carotid stenosis were flipped in the right-left orientation thus all hemispheres ipsilateral to the stenosis were aligned. For statistical comparisons, we used images of 25 age-sex matched healthy controls (7 women, mean age of 68 years). VBM analysis was performed with VBM8/SPM8 toolbox (two-sample T-Test, P<0.001 uncorrected). For DTI, we used the TBSS. After image alignment and mapping, the fractional anisotropy (FA) values were compared in order to detect possible differences between patients and controls.
RESULTS: We observed GM atrophy predominantly in areas supplied by the anterior circulation of the hemisphere ipsilateral to the stenosis (middle temporal gyrus, middle frontal gyrus, superior frontal gyrus, medial frontal gyrus). WM atrophy was diffuse and symmetrical in both ipsilateral and contralateral hemispheres in VBM and DTI analysis.
CONCLUSIONS: Our findings suggest that ACS/occlusion is associated with subtle GM reduction in the ipsilateral hemisphere possibly due to significant hemodynamic disturbance. This is in accordance with previous data demonstrating cognitive decline in these patients. The diffuse and symmetrical white matter abnormalities are probably associated with risk factors and chronic WM changes rather than the carotid disease.
Authors/Disclosures
Wagner M. Avelar, PhD
PRESENTER 		No disclosure on file
Anelyssa Cysne Frota D' Abreu, MD, PhD, MPH, FAAN (Corewell Health Outpatient Neurology) The institution of Dr. Cysne Frota D' Abreu has received research support from U.S. NIH Institute on Aging. The institution of Dr. Cysne Frota D' Abreu has received research support from Biogen. The institution of Dr. Cysne Frota D' Abreu has received research support from American College Of Radiology. The institution of Dr. Cysne Frota D' Abreu has received research support from COGNITION THERAPEUTICS, INC.. The institution of Dr. Cysne Frota D' Abreu has received research support from Eli Lilly. The institution of Dr. Cysne Frota D' Abreu has received research support from Jansen. Dr. Cysne Frota D' Abreu has received personal compensation in the range of $10,000-$49,999 for serving as a Lecturer with Pri_med.
David N. Franz, MD (CCHMC/MLC 2015) No disclosure on file
Ana C. Coan, MD (Unicamp) No disclosure on file
Fabricio O. Lima, MD No disclosure on file
Rachel P. Guimaraes, PT (Unicamp) Ms. Guimaraes has nothing to disclose.
Clarissa L. Yasuda, MD, PhD (University of Campinas) Prof. Yasuda has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for LIBBS. Prof. Yasuda has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ABBOTT. Prof. Yasuda has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for LIBBS.
Cynthia Herrera Campos, PhD No disclosure on file
Li M. Li, MD (Cidade Universitaria Zeferino Vaz) No disclosure on file
Fernando Cendes, MD, PhD, FAAN (Departamento de Neurologia; FCM; UNICAMP) Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB Pharma. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for UCB Biopharma. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for United Medical – Brazil. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Zodiac Pharma . Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eurofarma – Brazil . Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Epilepsia. Dr. Cendes has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Frontiers in Neurology - Epilepsy. The institution of Dr. Cendes has received research support from São Paulo Research Foundation - FAPESP. The institution of Dr. Cendes has received research support from Conselho Nacional de Desenvolvimento Científico e Tecnológico - Brazil . The institution of Dr. Cendes has received research support from NIH.