Abstract Details

Title Psychological Stress Induced-Salivary alpha-Amylase Secretion Decreases in Patients with Parkinson's Disease

Topic Movement Disorders

Presentation(s) P03 - (-)

Poster/Presentation
Number 070

Objective

Background BACKGROUND: sAA secretion is directly controlled by the SNS and sympathetic nervous-adrenal medullary system and is a reliable SNS biological stress marker. The autonomic nervous system is impaired in patients with PD. We hypothesized that stress-induced sAA secretion decreases in patients with PD compared with patients with other neurological diseases. Previously, we reported that stress induced-sAA used by the Trier Social Stress test (TSST) of patient with PD was significantly lower than control. However TSST is too complicated and sAA secretion post-TSST was not correlated with clinical data. In this study, we modified the method of psychological stress task.

Design/Methods DESIGN/METHODS: We studied 20 patients with PD and 20 control subjects with other central nervous system diseases. Participants were administered, psychological stress task (Serial sevens) for 3 minutes; the examiner asked the participant to count down from 100 by 7 as quickly and accurately as possible. When the participants completely finish counting down from 100 by 7 within 3 min, the participants restart at 1000. We measured secretion before (pre-Task) and just after the task (post-Task) using restriction enzyme analysis.

Results RESULTS: Post-Task sAA secretion in patients with PD was significantly lower than that in control subjects (158.1±71.7 vs. 78.9±91.9 p<0.05). Post-Task sAA was opposite correlated with UPDRS part 3 score. The deference between Pre-Task sAA and Post-Task sAA of patients with Hoehn and Yahr (H&Y) stage III to IV was significant lower than patients with H&Y stage I to II (25.1±71.9 vs. 51.7±61.3 P<0.05).

Conclusions CONCLUSIONS: sAA may detect early SNS dysfunction in patients with PD. sAA can be measured using a simple non-invasive procedure and may provide useful diagnostic information to distinguish PD from other parkinsonian disorders.

Authors/Disclosures
Kiyokazu Kawabe, MD (Department of Neurology Saiseikai Yokohamashi Tobu Hospital) PRESENTER	No disclosure on file
Osamu Kano, MD, PhD (Department of Neurology, Toho University Faculty of Medicine)	Dr. Kano has nothing to disclose.
Ken Ikeda, MD, PhD (Toho University Omori Medical Center)	No disclosure on file
Yasuo Iwasaki, MD	No disclosure on file
	No disclosure on file

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