Abstract Details

Title Does Weakness in Motor Neuron Disease Correlate with Triple Stimulation Technique Scores?

Topic Anterior Horn

Presentation(s) P07 - (-)

Poster/Presentation
Number 079

Objective

Background BACKGROUND: Triple stimulation technique(TST) using Transcranial Magnetic Stimulation(TMS),recorded from Abductor Digiti Minimi(TST-ADM) is useful in quantifying central conduction failure.In MND,weakness is often an early clinical manifestation.Establishing a relationship between clinical weakness and loss of function with UMN loss as measured by TST may help us better understand the possible neurophysiologic pathways and mechanisms responsible for the clinical features of MND.

Design/Methods DESIGN/METHODS: IRB approval was obtained.A total of 17 subjects with a diagnosis of MND with UMN findings on clinical examination underwent TST to quantify the degree of UMN loss.TST was recorded bilaterally from ADM.Grip force,pinch grip force,timed peg board and timed block tests were used for objective measures of upper extremity weakness and function.

Results RESULTS: Motor evoked responses from TMS for one study subject could not be elicited from the left motor cortex.Total of 33 nerves were studied using ADM-TST. The following findings were observed:Mean TST amplitude ratio:77.90%(±25.14%),mean TST area ratio of:77.57%(±25.97%),mean grip force:76.15lb(±43.80%),mean lateral pinch grip:14.23lb(±49.70%),mean timed peg board test score:21.78(±31.82%), mean timed block test score:59.17(±25.01%). Correlations significant at the level of 0.01 were observed between:1)TST amplitude ratio and TST area ratio[r(31)=0.903,p<0.01],2)TST amplitude ratio and timed block test [r(31)=0.50,p<0.01].Correlations significant at the level of 0.05 were observed between: 1)TST amplitude ratio and grip force testing scores[r(31)=0.354,p<0.05],2)TST area ratio and timed block test scores[r(31)=0.44,p<0.05].

Conclusions CONCLUSIONS: TST is a neurophysiological technique that allows quantification of UMN loss. Our study shows UMN loss is correlated with clinical weakness and loss of function in patients with MND.

Authors/Disclosures
Rahul Remanan, MBBS (Nanoveda) PRESENTER	No disclosure on file
	No disclosure on file
Mona Shahbazi (Hospital for Special Surgery)	No disclosure on file
Dale J. Lange, MD, FAAN (Lange Neurology, PC)	No disclosure on file
David S. Knopman, MD, FAAN (Mayo Clinic)	Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. The institution of Dr. Knopman has received research support from NIH.

��ɫ��

��ɫ��