Abstract Details

Title Clinical Profile of Indian Patients with Amyotrophic Lateral Sclerosis (ALS): A Retrospective Hospital Based Study

Topic Anterior Horn

Presentation(s) P07 - (-)

Poster/Presentation
Number 077

Objective

Background BACKGROUND: The clinical heterogeneity is well recognized feature in the ALS in the term of age of onset, duration of disease, extent of involvement and its natural course in various parts of world.

Design/Methods DESIGN/METHODS: Total 119 patients, admitted in the neurology unit from 2005 to 2009 with the discharge diagnosis of anterior horn cell disease or motor neuron disease (modified Airlie El Escorial criteria) were included. Patients with incomplete clinical data or improper records were excluded. All available clinical and epidemiological data were entered into in the excel sheet for analysis.

Results RESULTS: The male female ratio was 3.7:1. Six patients (5%) had familial ALS. The mean age of onset for all patients was 42.8±15.9 years, and duration of disease was 19.5±16.2 months. Men were younger at onset of disease than women (41.3±16.6 years vs 48.3±11.7 years, p =0.018), but had delayed presentation to hospital (20.9±17.4 months vs 14.3±9.3 months, p value =0.01). Fifty-six patients (70%) out of 80 patients (age of onset >40 years) had bulbar onset ALS whereas it was involved in only 14 patients (35.9%) with age <40 years. Upper limb onset ALS was commonest presentation (53.8%) followed by lower limb and bulbar onset (26.1% and 20% respectively). Clinical and/or electrophysiological evidence of cervical spinal segment, lumbo-sacral, bulbar and thoracic involvement were present in 95.8%, 78.2%, 56.3% and 55.5% patients respectively. Definite, probable and possible ALS was 62.2%, 16.8% and 14.3% respectively.

Conclusions CONCLUSIONS: Indian ALS patients were younger at onset of disease. Men were younger than women at onset of disease, but had delayed presentation to hospital. Bulbar onset ALS was more frequent in elderly patients. Differential presentation of ALS in men and women needs further evaluation including genetic/hormonal influence.

Authors/Disclosures
Nirendra K. Rai, MD (Medilearn India) PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Achal K. Srivastava, MD, FAAN (AIIMS)	Dr. Srivastava has nothing to disclose.
Madhuri Behari, MD (All India Institute of Medical Science)	No disclosure on file
	No disclosure on file

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