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Abstract Details

A Change in Waist to Hip Ratio Inversely Correlates with a Change in Executive Function Abilities in Older Adults
Aging and Dementia
P03 - (-)
101
BACKGROUND: Past research suggests that a high waist to hip ratio (WHR) in midlife corresponds with a greater decline in total brain volume and executive function over time. Less is known about the impact of short-term changes in WHR. Our study investigates the association between longitudinal change in WHR and change in executive functioning (EF) in non-demented older adults.
DESIGN/METHODS: We obtained WHRs and EF composite scores for 89 non-demented older adults at baseline (mean age = 77.3, sd=6.4) and again approximately one year later (mean interval = 14 months卤3.1. The EF composite scores were generated using item response theory several measures of cognitive control, fluency, and working memory. A Pearson's Partial Correlation controlling for age at first time point was used to assess the relationship between change in WHRs and change in EF.
RESULTS: Change in WHR and change in EF abilities were inversely correlated (r=-.214; p=.046) independent of age. Follow-up regression analyses indicated that an increase in waist size predicted decline in EF, even after controlling for hip size.
CONCLUSIONS: The results of this study suggest WHR and EF are related over time independent of age. While causality cannot be inferred, these results are consistent with studies showing central adiposity as a risk factor for cognitive decline. Alternately, gluteofemoral fat might serve as a protective factor for EF, or declines in EF may predispose participants toward less healthy diets.
Authors/Disclosures
Christa Watson (UCSF)
PRESENTER 		No disclosure on file
Brianne Bettcher No disclosure on file
No disclosure on file
Bianca Weinstock-Guttman, MD (Department of Neurology, University At Buffalo) Dr. Weinstock-Guttman has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genzyme &Sanofi. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bayer. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Horizon. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving as a Reviewer with NIH.
Dan M. Mungas, PhD Dr. Mungas has nothing to disclose.
Bruce R. Reed, PhD (UC Davis Alzheimer's Disease Ctr) No disclosure on file
Wendy Mack No disclosure on file
Helena C. Chui, MD (University of Southern California) The institution of Dr. Chui has received research support from National Institute on Aging .
Joel Kramer, PhD (UCSF Medical Center) The institution of Dr. Kramer has received research support from tau consortium. Dr. Kramer has received publishing royalties from a publication relating to health care.