Abstract Details

Title Correlation of High-Frequency Oscillations in Focal Hand Dystonia with Therapeutic Response after Botulinum Toxin Treatment

Topic Movement Disorders

Presentation(s) P07 - (-)

Poster/Presentation
Number 194

Objective

Background BACKGROUND: Pathophysiology of focal hand dystonia (FHD) remains largely unknown as well as effective therapy. Abnormal high-frequency oscillations (HFOs) in FHD suggest dysfunction in somatosensory processing. Since effects of botulinum toxin treatment in FHD may be mediated by altered somatosensory input, we aimed to investigate the relationship between changes in HFOs and response to botulinum toxin therapy in FHD.

Design/Methods DESIGN/METHODS: 16 subjects with unilateral FHD, 8 with writer's cramp and 8 with musician's dystonia, and 8 healthy controls were studied using median nerve stimulation on both sides and recording with a 275 channel MEG system. HFOs were isolated by 450-1000 Hz band-pass filtering and global energy was calculated over a time window of interest (15-25 ms post stimulation). Time frequency analysis was used to quantify the change in energy of high frequency oscillation (450-1000 Hz) modulation prior to and post botulinum toxin treatment.

Results RESULTS: The power of the HFOs correlates with the response to botulinum toxin therapy. There are no differences of HFO in the affected and unaffected hand in FHD, and no differences in writer's cramp and musician's dystonia.

Conclusions CONCLUSIONS: The increase of HFO with effective botulinum toxin therapy suggests a possible mechanism of action that would be mediated by somatosensory processing. Exactly how botulinum toxin can influence sensory processing is not yet clear.

Authors/Disclosures
David H. Benninger, MD (University Hospital of Lausanne (CHUV)) PRESENTER	No disclosure on file
Peter T. Lin, MD (Valley Parkinson Clinic)	No disclosure on file
	No disclosure on file
	No disclosure on file
Kazumi Iseki (National Institutes of Health (NIH))	No disclosure on file
	No disclosure on file
Ou Bai, PhD	No disclosure on file
Mark Hallett, MD, FAAN (National Institutes of Health)	Dr. Hallett has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Hallett has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurocrine. Dr. Hallett has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Brainsway. Dr. Hallett has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for VoxNeuro. Dr. Hallett has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for QuantalX. Dr. Hallett has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Hallett has received intellectual property interests from a discovery or technology relating to health care. Dr. Hallett has received publishing royalties from a publication relating to health care. Dr. Hallett has received publishing royalties from a publication relating to health care. Dr. Hallett has received publishing royalties from a publication relating to health care. Dr. Hallett has received publishing royalties from a publication relating to health care. Dr. Hallett has received personal compensation in the range of $500-$4,999 for serving as a Speaker with International Parkinson and Movement Disorder Society. Dr. Hallett has a non-compensated relationship as a Past-President with Functional Neurological Disorder Society that is relevant to AAN interests or activities.

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