Abstract Details

Title Does Intracranial Large Vessel Stenosis Correlate with Burden of Small Vessel Ischaemia?

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P01 - (-)

Poster/Presentation
Number 240

Objective

Background BACKGROUND: Intracranial atherosclerotic disease is a major cause of ischaemic stroke worldwide and is identified as intracranial stenosis (ICS). White matter hyperintensities (WMH) and microbleeds have been well-described as markers of small vessel disease, which is well-established as an important cause of stroke. Limited data is available on the correlation of neuroimaging markers of large and small vessel disease.

Design/Methods DESIGN/METHODS: Retrospective review of ischaemic stroke patients attending a tertiary outpatient setting between 2008 and 2012. Post-stroke patients with magnetic resonance imaging and magnetic resonance angiography (MRA) were included. ICS was rated using MRA score; WMH and microbleeds were scored using modified Fazekas scale (range 0-12) and Microbleed Anatomical Rating Scale (MARS) respectively. We recorded patients' demographics and cardiovascular risk factors (CVRF).

Results RESULTS: 229 patients met the inclusion criteria. Mild ICS was defined as MRA score <3 and severe ICS as MRA score ? 3. Presence of ICS was significantly associated with increasing age, higher fasting blood sugar, greater WMH and more microbleeds. After adjusting for age, gender, race and cardiovascular risk factors, both WMH and microbleeds were found not to be independently predictive of ICS. Correlation analyses also did not demonstrate a significant correlation between location-specific periventricular WMH, deep WMH or microbleeds to corresponding location of ICS.

Conclusions CONCLUSIONS: Severity of large vessel disease does not correlate with burden of small vessel ischaemia. These findings suggest difference in pathophysiology of large and small vessel diseases.

Authors/Disclosures
Xuling Lin, MD (National Neuroscience Institute) PRESENTER	The institution of Dr. Lin has received research support from National Health Innovation Center.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Frank Bennett, PhD	No disclosure on file
Nagaendran Kandiah, MD (National Neuroscience Institute)	No disclosure on file

��ɫ��

��ɫ��