Abstract Details

Title Variants, Clinical Characteristics and Prognostic Factors of Guillain Barre Syndrome in Chinese

Topic Peripheral Nerve

Presentation(s) P01 - (-)

Poster/Presentation
Number 135

Objective

Background BACKGROUND: The variants, clinical characteristics and prognostic factors of adults with GBS in Hong Kong has not been widely studied previously.

Design/Methods DESIGN/METHODS: We performed a retrospective review of adults with GBS admitted to Queen Mary Hospital, Hong Kong during the period 1997-2011.

Results RESULTS: Mean age of the patients was 57+/-17 years and the mean hospital stay was 36+/-69 days. Male:female ratio was 1.5:1. Of the 63 patients with GBS, 4.8% had acute motor axonal neuropathy, 17.5% with Miller-Fisher syndrome and 77.8% were of the acute inflammatory demyelinating polyneuropathy together with other unspecified subtypes. 49.2% had preceding upper respiratory tract illness, 4.76% preceding gastrointestinal illness, whilst 7.94% received vaccination during the 6weeks preceding onset of neurological symptoms. 22.2% patients were admitted to Intensive Care Unit and 12.7% patients required mechanical ventilation. 19.0% patients were treated conservatively, 39.7% received intravenous immunoglobulin only, 30.2% received plasmapharesis only and 11.0% received both intravenous immunoglobulin and plasmapharesis. 36.1% of patients was associated with poor functional recovery (requiring walking with aid at 6months after admission). Multivariate analysis revealed that necessity of mechanical ventilation during hospitalization (Odds Ratio = 43.3, 95% confidence interval: 1.2-1539.4, p=0.039) was an independent predictor of poor functional recovery at 6months after admission. Receiver Operating Characteristics curve also showed that an Erasmus GBS Outcome Score>4 was associated with good functional recovery with area under Receiver Operating Characteristic Curve being 0.87 (p<0.0001).

Conclusions CONCLUSIONS: Miller Fisher syndrome is more common in the Chinese population compared to the West. Necessity of mechanical ventilation during hospitalization is an independent predictor of poor functional recovery and the Erasmus GBS Outcome Score is a useful score in predicting functional recovery.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Yuen Kwun Wong	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Raymond T. Cheung, MD, FAAN (University of Hong Kong)	No disclosure on file
Ronald M. Lazar, PhD, FAHA, FAAN, FAAN (University of Alabama At Birmingham)	Dr. Lazar has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DiaMedica Therapeutics Inc. . The institution of Dr. Lazar has received research support from National Institutes of Health. Dr. Lazar has received publishing royalties from a publication relating to health care.
Shu Leong Ho, MD, FAAN (Gleneagles Hospital Hong Kong)	No disclosure on file
	No disclosure on file
Gary K. Lau, MBBS (University of Hong Kong)	Dr. Lau has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Amgen. Dr. Lau has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Lau has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Daiichi Sankyo. Dr. Lau has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Amgen. Dr. Lau has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Boehringer Ingelheim. Dr. Lau has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Daiichi Sankyo. Dr. Lau has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Pfizer. Dr. Lau has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Eisai. Dr. Lau has stock in ReMobility. The institution of Dr. Lau has received research support from Croucher Foundation. The institution of Dr. Lau has received research support from Research Fund Secretariat of the Food and Health Bureau, Hong Kong. The institution of Dr. Lau has received research support from Innovation and Technology Bureau, Hong Kong. The institution of Dr. Lau has received research support from Research Grants Council, Hong Kong. Dr. Lau has received publishing royalties from a publication relating to health care.

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