Abstract Details

Title Tau Platelets Biomarker Correlates with Clinical Features of Alzheimer's Disease

Topic Aging and Dementia

Presentation(s) P03 - (-)

Poster/Presentation
Number 076

Objective

Background BACKGROUND: Tau hyperphosphorylation is the common final step in all the altered signaling pathways in degenerating neurons in AD. Moreover, tangle (NFT) formation has been identified as a major event involved in the neurodegenerative process, due to the conversion of either soluble tau (LMWtau) or oligomers (HMWtau) into insoluble filaments. The relationship between peripheral tau and AD has not been previously explored.

Design/Methods DESIGN/METHODS: Blood samples were taken from 44 AD patients (age 71.8+/-7.03) and from 38 normal controls (age: 71.03+/-5.34). The platelets were separated and the analysis of tau species carried out by electrophoretic separation and western blots, followed by densitometric scanning of tau immunoreactive bands. Correlation between brain atrophy and peripheral tau platelet were analyzed in 30 AD patients with MRI and voxel-based morphometry (VBM).

Results RESULTS: The levels of both HMWtau and LMWtau were not different between groups, however the HMW/LMW ratio differed significantly between controls (mean ratio: 1.51 +/-0.68) and patients (mean ratio: 2.07 +/-1.27) (t-test: 1.80 = -2.56; p = 0.013). The VBM analysis showed a correlation between the tau biomarker and hippocampal volume (p<0.001 corrected for multiple comparison).

Conclusions CONCLUSIONS: These findings indicated that platelet tau species could be use as biomarker for AD. In addition, this finding has implications for the development of biomarkers for other tau-based neurodegenerative diseases.

Authors/Disclosures
Andrea Slachevsky, MD PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Sharon Tamir	No disclosure on file
	No disclosure on file
Gonzalo Farias, MD	No disclosure on file
Oscar L. Lopez, MD, FAAN	Dr. Lopez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acumen.
James T. Becker, PhD (University of Pittsburgh)	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file

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