好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Relationship between White Matter Integrity and Emotional Blunting in Frontotemporal Dementia and Early-Onset Alzheimer's Disease
Aging and Dementia
P05 - (-)
106
BACKGROUND: White matter abnormalities have been associated with both bvFTD and AD. Emotional blunting, which refers to loss of emotional warmth, sympathy or empathy, is a characteristic feature of bvFTD.
DESIGN/METHODS: We studied 7 bvFTD and 8 AD participants. Four DTI metrics (fractional anisotropy [FA], axial diffusivity [AxD], radial diffusivity [RaD], and mean diffusivity [MD]) were assessed for two corpus callosum regions: the genu (GWM), which connects the prefrontal cortices, and the splenium (SWM), which connects posterior regions containing axons involved in visual processing. The Emotional Blunting Scale (EBS) was used to assess the emotional functioning of study participants.
RESULTS: Spearman's rank-order correlations were performed and significant associations were observed between EBS ratings and GWM DTI measures including FA (r=-0.689, p=.005), AxD (r=0.567, p=.028), RaD (r=0.658, p=.008), and MD (r=0.708, p=.003). When the two clinical groups were examined separately, these relationships remained robust for the bvFTD group but not the AD group. The correlations between EBS and SWM DTI metrics were not statistically significant in the combined sample, but within the bvFTD group, highly significant relationships were elucidated between EBS and AxD (r=0.883, p=.009) and MD (r=0.955, p=.0008), but not FA (r=0.432, p=.289) or RaD (r=0.072, p=.878).
CONCLUSIONS: These results demonstrate a significant relationship between white matter breakdown and symptoms of emotional blunting, particularly within the bvFTD group. Because there were significant correlations with both genu and splenium, the EBS-white matter relationship does not appear to be regionally specific. In the splenium, EBS was associated with DTI metrics that are reflective of axonal size (AxD and MD) but not those specifically sensitive to myelin.
Authors/Disclosures
Po-Haong Lu
PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
Natalie Kaiser (West Los Angeles VA Medical Center) No disclosure on file
Adriano Chio, MD, FAAN (Dept. of Neuroscience, University of Turin) Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cytokinetics. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Corcept.
No disclosure on file
No disclosure on file
No disclosure on file
George Bartzokis, MD No disclosure on file
Mario F. Mendez, MD, PhD, FAAN (VA Greater Los Angeles Healthcare System and UCLA) Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medical 好色先生 Speakers' Bureau. Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for UpToDate. The institution of Dr. Mendez has received research support from NIH. Dr. Mendez has received publishing royalties from a publication relating to health care.