Abstract Details

Title Safety and Efficacy of Excitatory Repetitive Deep Transcranial Magnetic Stimulation with H-Coil: An Open Study in 24 Patients with Parkinson's Disease

Topic Movement Disorders

Presentation(s) P04 - (-)

Poster/Presentation
Number 185

Objective

Background BACKGROUND: Repetitive transcranial magnetic stimulation has proved to be able to modify cortical excitability and to be effective in Parkinson's disease, especially when applied with high frequencies.

Design/Methods DESIGN/METHODS: 24 PD-patients (aged 60 ± 6.7; PD-duration: 6.6 ±3; motor Unified Parkinson's Disease Rating Scale-UPDRSIII: 38.8 ± 10.5) underwent 12 DTMS sessions in 4 weeks, over primary motor (M1) of the most affected hemisphere and bilateral prefrontal (PF) regions at excitatory 10Hz frequency. Clinical assessment included total UPDRSIII and partial scores, for the worse (WS) or less affected (LS) PD-side, for axial involvement (AS), tremor (TS) and rigidity (RS). Four timed tests (arm tapping-AT; Nine Hole Peg Test- NHPT; foot tapping- FT; walking- W) were also performed. Patients were evaluated OFF therapy at baseline (T0), after the first (T1) and the last (T2) DTMS-session. Both clinicians and patients were not blind to the stimulation. An analysis for repetitive measures was performed.

Results RESULTS: DTMS is a safe (no drop-out; no adverse events) and effective PD-treatment, showing a significant improvement in UPDRSIII at every time-point, with a reduction of 16% and 23% at T1 (p<0.001) and T2 (p<0.001). Similar results were also obtained comparing subscores for WS, LS, AS, TS and RS. Improved performance in timed tests was also observed, except for W, which did not reach significance.

Conclusions CONCLUSIONS: despite the lack of blindness, DTMS is a safe and promising new therapeutic perspective in PD. Further placebo controlled, randomized studies are granted to assess its therapeutic efficacy.

Authors/Disclosures
Francesca Spagnolo PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Raffaella Chieffo, MD	No disclosure on file
	No disclosure on file
	No disclosure on file
Arturo Nuara	No disclosure on file
Dacia Dalla Libera, MD (San Raffaele Hospital)	No disclosure on file
	No disclosure on file
	No disclosure on file
Alastair Compston, PhD, FRCP	No disclosure on file
	No disclosure on file
	No disclosure on file
Giancarlo Comi, MD (University Vita-Salute)	Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.
	No disclosure on file
Letizia M. Leocani, MD (University Vita-Salute San Raffaele, INSPE)	Dr. Leocani has received personal compensation in the range of $0-$499 for serving as a Consultant for Roche . Dr. Leocani has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Leocani has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bristol Myers Squibb. Dr. Leocani has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Med-ex learning.

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