Abstract Details

Title Autoimmune Myasthenia Gravis and Thyroid Disease in Argentina

Topic Muscle Disease/Neuromuscular Junction

Presentation(s) P02 - (-)

Poster/Presentation
Number 200

Objective

Background BACKGROUND: Autoimmune myasthenia gravis (MG) is usually associated with other autoimmune diseases. Of these, the most frequent is Thyroid Disease (TD). According to different series the prevalence of this association is about 10%.

Design/Methods DESIGN/METHODS: We review medical records of MG patients at the Neuromuscular Diseases Section of the Hospital Italiano de Buenos Aires. We regard demographic clinical and serological characteristics and compare this data between patients with and without thyroid disease.

Results RESULTS: 189 patients with MG were included. Of these, 24.9% (47) had thyroid disfunction. 23.3% (44) were hypothyroid and 1.6% (3) hyperthyroid. The median age of onset was 58±17 years (24-88) and 87.2% (41) were women. 21.3% (10) were ocular and 78.7% (37) had the generalized form of MG. 38.2% had AchR antibodies. Thymic pathology: 66% were normal, 17 % had hyperplasia, 4.3% thymic fat and 12.8% had thymoma. Female gender was more frequent in the MG-TD group (p=0.002). The median age at onset, clinical form of MG, presence of AchR antibodies and severity were not different between groups. Thymoma was more frequent in the MG-TD group (p=0.03, OR 3.31), while the rest of thymic pathology were similar.

Conclusions CONCLUSIONS: This is the largest review of the clinical features of MG patients with and without thyroid disease (TD) to date in our country. The prevalence of TD was higher than previously reported, being hypothyroidism the most frequent finding. The high rate of thymoma in the MG-TD group is another remarkable data in our serie.

Authors/Disclosures
Mariela Bettini, MD (Hospital Italiano DE. BS. AS.) PRESENTER	Dr. Bettini has nothing to disclose.
Marcelo Chaves (Merck Serono Argentina)	No disclosure on file
	No disclosure on file
Edgardo Cristiano, MD (Hospital Italiano De Buenos Aires)	Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Genzyme. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck.
Marcelo F. Rugiero, MD	No disclosure on file
Anthony Traboulsee, MD (University of British Columbia)	Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Traboulsee has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Traboulsee has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for EMD Serono. Dr. Traboulsee has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Roche. The institution of Dr. Traboulsee has received research support from Roche. The institution of Dr. Traboulsee has received research support from Consortium of MS Centers. The institution of Dr. Traboulsee has received research support from MS Canada. Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving as a Workshop Chair with Consortium of MS Centers.

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