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Abstract Details

Impaired Kidney Function and Cerebral Microbleeds in Patients with Ischemic Stroke and Transit Ischemic Attack
Cerebrovascular Disease and Interventional Neurology
P07 - (-)
221
BACKGROUND: Renal and cerebral vascular similarities explain the relationship between impaired glomerular filtration rate (iGFR) and the presence of lacunar infarcts and leukoaraiosis. Microbleedings, another radiologic manifestation of cerebral small vessel pathology, might also be associated with iGFR.
DESIGN/METHODS: Patients with cerebral ischemic events were prospectively evaluated with gradient echo MRI in order to assess presence, number and location of cerebral microbleeds. Demographic data, vascular risk factor profile and stroke subtype were obtained in every patient. GFR was estimated with the Cockcroft-Gault formula, and iGRF was defined as lower as 60 ml/min/1.73 m2.
RESULTS: 98 patients (21%) of the 463 evaluated individuals, had cerebral microbleeds. We found that the most common lesion locations were deep or infratentorial (79%, n 73). Risk factors associated with microbleeds in the univariate analysis were: age, atrial fibrillation, renal failure and leukoaraiosis. Only leukoaraiosis (OR 3.2; CI 95% 1.7-6.2), age older than 80 years (OR11; CI 95% 4.6-27.2) and iGFR (OR 2.7; CI 95% 2.1-8.2) were associated with the presence of cerebral microbleeds in the multivariate analysis. GFR was lower in patients with cerebral microbleeds (70 卤 27 vs 52 卤 16 ml/min/1.73 m2).
CONCLUSIONS: Impaired kidney function is associated with the presence of cerebral microbleeds in patients with ischemic stroke.
Authors/Disclosures
Maria C. Zurru, MD
PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Aaron E. Miller, MD, FAAN (Mt Sinai School Of Med) Dr. Miller has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Accordant Health Services (Caremark). Dr. Miller has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Corevitas (formerly known as Corrona). Dr. Miller has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for MAPI=Pharma. Dr. Miller has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Viatris (Mylan). Dr. Miller has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Guidepoint Global. Dr. Miller has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Gerson Lehrman Group. Dr. Miller has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Biogen Idec. Dr. Miller has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Alexion. Dr. Miller has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Amgen (Horizon Therapeutics). Dr. Miller has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for Sterne Kessler. Dr. Miller has received publishing royalties from a publication relating to health care.
Edgardo Cristiano, MD (Hospital Italiano De Buenos Aires) Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Genzyme. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck.