Abstract Details

Title Relationship of Self-Reported Home Seizure Frequency to Seizure Occurrence and Time to Seizure Onset in Children Undergoing Presurgical Workup in the Long Term Monitoring Unit

Topic Epilepsy

Presentation(s) P05 - (-)

Poster/Presentation
Number 095

Objective

Background BACKGROUND: Data on seizure-occurrence in children undergoing presurgical LTM is lacking. Children undergoing monitoring for epilepsy surgery require longer duration of expensive monitoring and can increase the risk for prolonged seizures.

Design/Methods DESIGN/METHODS: We retrospectively collected data on ninety-five patients admitted to LTM unit. Home seizure-frequency was defined as low (up-to 1/month), medium (up-to 1/week) and high (>1/week). Relationship between seizure-occurrence and home seizure-frequency was analyzed by logistic regression, and between time-to-seizure-onset and home seizure-frequency by Cox Proportional Hazards and Kaplan-Meier survival models.

Results RESULTS: Twenty-two patients were in low, eighteen in medium and fifty-five in high-frequency group. Eighty-eight patients had at-least one seizure during monitoring. Odds of first-seizure increased by 15.88 in high vs. low-frequency group (p=0.01), and by 10.4 in medium-high vs. low-frequency group (p=0.0076). Hazard rate for first-seizure in high-frequency group was 2.17 times higher than low-frequency group (p=0.006), and 2.06 times higher for high-medium frequency group than low-frequency group (p=0.008). Time-to-onset of first-seizure was lesser in high-frequency group than low-frequency group (p=0.0004); and in medium-high frequency group than low-frequency group (p=0.0007). Odds of second-seizure increased by 37.38 in high vs. low-frequency group (p=0.001), and by 11.77 in medium vs. low-frequency group (p=0.027). Home seizure-frequency did not significantly predict time-to-onset of second-seizure in any three categories. Odds of >3 seizures increased by 3.6 in high vs. low-frequency group (p=0.03), by 5.7 in medium-high vs. low-frequency group (p=0.0008). Other factors (age/gender/seizure-localization/prolonged-seizure/neuro-exam) were not significant predictors for odds/time-to-onset/hazard-rate of first-seizure (p>0.05).

Conclusions CONCLUSIONS: Of all factors examined only home-seizure frequency correlated with occurrence and time-to-onset of seizures during monitoring. Low-frequency patients are less likely to have multiple seizures which can affect successful completion of pre-surgical monitoring.

Authors/Disclosures
PRESENTER	No disclosure on file
Sanjeev V. Kothare, MD, FAAN (Cohen Children's Hospital, Northwell Health)	Dr. Kothare has nothing to disclose.
Masanori Takeoka, MD (Children'S Hospital Boston)	No disclosure on file
Tobias Loddenkemper, MD, FAAN	No disclosure on file
	No disclosure on file
	No disclosure on file

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