Abstract Details

Title MR Elastography (MRE) for the Differentiation of Intracranial Tumors - Results of a Histology Correlated Study

Topic Neuro-oncology

Presentation(s) P07 - (-)

Poster/Presentation
Number 010

Objective

Background BACKGROUND: The non-invasive differentiation of brain tumors has remained dissatisfying, the majority of neurooncology patients still need to undergo brain biopsy in order to make a diagnosis.

Design/Methods DESIGN/METHODS: Sixteen patients with suspected intracranial malignoma and planned biopsy / surgery were selected from neuroradiological routine. MR elastography was performed on an 3 Tesla MRI scanner (Philips Achieva), applying motion encoding EPI sequences in three directions and monofrequent shear wave generation by a head cradle as previously described. Viscoelasticity was measured for tumor tissue as well as for healthy white matter as reference tissue.

Results RESULTS: The study population comprised of n=16 intracranial tumors, among these meningeomas (n=2), solitary metastasis (n=3), as well as WHO grade II - IV tumors (n=10). Compared to reference tissue, meningeomas were obvious more firm. Metastases were either slightly firmer or softer than reference tissue. WHO grade II and III tumors (n=6) were obvious softer than white matter in all cases. The softest tissue parameters were represented by WHO grade IV tumors. Viscoelasticity parameters were supplemented by an extensive histopathology work-up. High WHO grade tumors were significantly softer than tumors of lower staging, the range of metastatic viscoelasticity was slightly higher compared to primary brain tumors. MRE was well-tolerated by all patients and is feasible for clinical routine application.

Conclusions CONCLUSIONS: MR elastography of cerebral tumors at 3 Tesla reliably quantifies tumor tissue firmness for preoperative planning. According to our histology correlated preliminary results, tumor viscoelasticity may be an additional diagnostic parameter for non-invasive tumor differentiation by MRI.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
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	No disclosure on file
Jens Wuerfel, MD (Hoffmann-LaRoche)	Dr. Wuerfel has received personal compensation for serving as an employee of MIAC AG. The institution of Dr. Wuerfel has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Actelion. The institution of Dr. Wuerfel has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. The institution of Dr. Wuerfel has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche.
Bianca Weinstock-Guttman, MD (Department of Neurology, University At Buffalo)	Dr. Weinstock-Guttman has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genzyme &Sanofi. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bayer. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Horizon. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving as a Reviewer with NIH.

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