Abstract Details

Title Parkinson's Disease and Narcolepsy

Topic Sleep

Presentation(s) P05 - (-)

Poster/Presentation
Number 027

Objective

Background BACKGROUND: Excessive daytime sleepiness and sleep attacks are common in PD. These symptoms are also described in Narcolepsy. There is evidence to support an increasing loss of hypocretin cells (Hcrt) in the brains of PD patients with disease progression. However, the understanding of clinical association of Parkinson's disease and Narcolepsy remains unclear. Awareness of clinical narcoleptic type phenomenon in PD is important for optimal management and safety considerations in these patients.

Design/Methods DESIGN/METHODS: 100 consecutive PD patients were assessed with respect to subjective sleepiness using Epworth Sleepiness Scale (ESS). They were also questioned using our standard questionnaire regarding other associated clinical features of narcolepsy : Cataplexy (2 items) Hypnagogic and/or Hypnopompic hallucinations (2 items), Sleep paralysis( 3 items). The responses were compared between the sleepy (ESS>10) and non-sleepy (ESS<10) subjects.

Results RESULTS: 55 subjects (96.4% men, 89% W, mean age 72.7, mean H&Y 2.85) had ESS > 10 (mean 14.69, 95% CI 13.79-15.59). 45 subjects (97.8% men, 82% W, mean age 72.1, mean H&Y 2.58) had ESS ? 10 (mean 6.98, 95% CI 6.18-7.77). ESS > 10: 19 endorsed symptoms suggestive of cataplexy, 23 of hypnagogic and/or hypnopompic hallucinations, 27 of sleep paralysis. 24/55: reported two or more of the above mentioned symptoms. ESS ? 10: 11 endorsed symptoms suggestive of cataplexy, 14 of hypnagogic and or hypnopompic hallucinations, 14 of sleep paralysis. 12/45: reported two or more of the above mentioned symptoms.

Conclusions CONCLUSIONS: Symptoms suggestive of Narcolepsy are common in Veterans with Parkinson's disease. Although cataplexy and other associated symptoms of Narcolepsy are significantly more common in those suffering from excessive sleepiness, they are also endorsed by those not reporting excessive sleepiness. This phenomenon needs to be studied further.

Authors/Disclosures
Aliya Sarwar, MD (Baylor College of Medicine/ MEDVAMC) PRESENTER	Dr. Sarwar has received personal compensation in the range of $500-$4,999 for serving as a Amneal Fellowship Director Advisory Board Member with Amneal -Rytary.
Max Hirshkowitz, PhD (Veterans Admin Med Center)	No disclosure on file
	No disclosure on file

��ɫ��

��ɫ��