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Abstract Details

Complications Associated with Intrathecal Baclofen Administration - Our Experience
Neural Repair/Rehabilitation
P03 - (-)
270
BACKGROUND: Pharmacological side effects of ITB, surgical complications, and device-related complications are usually the main problems. In this study, we reported our experience with ITB treatment in past 10 years.
DESIGN/METHODS: Based on positive test trials with ITB we have implanted 37 pump systems (5x Synchromed EL, 32x Synchromed II, Medtronic) for severe spasticity in multiple sclerosis (13 cases) and in spinal cord injury (16 cases). Implantation technique was routine except one partial hemilaminectomy in patient with ankylosing spondylitis.
RESULTS: Overall we observed 14 complications (38%) with ITB treatment. Catheter-related complications developed in six patients. Three patients had local catheter infection and were successfully treated with antibiotics. Twice we observed cerebrospinal fluid leaks, once with the fluid subcutaneous fistula with necessity of surgical resolve. Two pumps had to be explanted, one due to infection and one due to pump failure.
CONCLUSIONS: Most complications were connected with catheter and were surgically treatable. Although intrathecal drug delivery systems are associated with various side effects and complications, their benefits outweigh the risk. Prevention, early recognition, and prompt management optimize the patient outcomes.
Authors/Disclosures
Ivana Stetkarova, MD, PhD (Charles University, Third Faculty of Medicine, Department of University)
PRESENTER 		Ivana Stetkarova, MD, PhD has nothing to disclose.
Aaron L. Boster, MD (Ohiohealth) Dr. Boster has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for sanofi. Dr. Boster has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for roche. Dr. Boster has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for novartis. Dr. Boster has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medtronic. Dr. Boster has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Serono. The institution of Dr. Boster has received research support from Sanofi. The institution of Dr. Boster has received research support from Roche.