Abstract Details

Title Autonomic Testing Does Not Differentiate Subjects with Interstitial Cystitis from Healthy Controls

Topic Autonomic Disorders

Presentation(s) P03 - (-)

Poster/Presentation
Number 030

Objective

Background BACKGROUND: IC/BPS presents with medically unexplained urinary urgency, frequency, nocturia, and elevated pelvic pain when the bladder is full. Autonomic dysfunction associated co-morbid disorders include irritable bowel syndrome, migraine and fibromyalgia.

Design/Methods DESIGN/METHODS: This prospective, IRB approved study evaluated at rest autonomic function of adult females with IC/BPS and matched female healthy controls. The healthy controls underwent a detailed neurologic evaluation prior to enrollment to ensure their true "healthiness". All subjects underwent the cardiac response to deep breathing and Valsalva maneuver, tilt table test and sudomotor function. The Composite Autonomic Severity Score includes a sudomotor index, an adrenergic index and a cardiovascular heart rate index.

Results RESULTS: 17 healthy females (mean age 35 +/- 16 yrs; mean BMI 35) and 15 females (mean age 39 +/- 18 yrs; mean BMI 29) with IC/BPS were enrolled. There was no statistical difference in the sudomotor or cardiovascular heart rate index. The adrenergic function was significantly different due to 1 severely abnormal Valsalva response in the IC/BPS group. The heart rate increase in the first 10 minutes of tilt was also not different between the 2 groups.

Conclusions CONCLUSIONS: Based on this initial sample, IC/BPS cannot, at this time, be characterized by abnormalities of autonomic testing. Completed enrollment for this study could change this preliminary conclusion. A dysautonomia (defined by classical autonomic test findings) may not be the linchpin that connects and explains associated symptoms of IC/BPS. This study does not exclude other types of autonomic dysfunction.

Authors/Disclosures
Thomas C. Chelimsky, MD (Medical College of Wisconsin) PRESENTER	Dr. Chelimsky has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Proctor & Gamble. Dr. Chelimsky has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Various Legal Firms. Dr. Chelimsky has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Various Legal Firms. Dr. Chelimsky has received stock or an ownership interest from PainSTakers, LLC. The institution of Dr. Chelimsky has received research support from NIDDK. The institution of Dr. Chelimsky has received research support from Advancing a Healthier Wisconsin.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Clifford R. Jack, Jr., MD (Mayo Clinic)	The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic.

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