Abstract Details

Title Spontaneous Confabulation in Bilateral Anterior Temporal Lobe Deficits with Largely Preserved Executive Functions

Topic Behavioral Neurology

Presentation(s) P05 - (-)

Poster/Presentation
Number 115

Objective

Background BACKGROUND: Spontaneous confabulation constitutes a syndrome of derangement of thought where patients past experience and habits disrupt normal judgment, planning and the adaptation of thought to ongoing reality. One prominent theory to explain spontaneous confabulation suggests an impaired awareness of the flow of time in memory. Posterior orbitofrontal cortex together with the basal forebrain are thought to be common sites of lesion in these deficits.

Design/Methods DESIGN/METHODS: Case Study.

Results RESULTS: Spontaneous and provoked confabulation along with significant anterograde amnesia was noted in a 70-year-old man following bilateral hippocampus and anterior temporal lobe lesions following viral encephalitis. Three months after the acute event confabulation and memory loss persisted and he was assessed for other cognitive deficits. Significant deficits in anterograde memory and naming but little to no difficulty in other cognitive domains was noted. We note relatively preserved basal frontal brain regions on structural MRI and on FDG PET along with largely intact executive frontal lobe functions but significant memory retrieval deficits for both personal and non personal details.

Conclusions CONCLUSIONS: Preserved connections to anterior temporal structures might be crucial for avoiding spontaneous confabulation in addition to frontal lobe structures.

Authors/Disclosures
Jagan Pillai, MD, PhD, FAAN (Cleveland Clinic) PRESENTER	Dr. Pillai has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Springer Nature. Dr. Pillai has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Current Treatment Options in Neurology. The institution of Dr. Pillai has received research support from Alzheimer's Association. The institution of Dr. Pillai has received research support from Keep Memory Alive Foundation . The institution of Dr. Pillai has received research support from NIA. Dr. Pillai has received personal compensation in the range of $500-$4,999 for serving as a Reviewer with DOD. Dr. Pillai has received personal compensation in the range of $500-$4,999 for serving as a Reviewer with RGC Hong kong.
Neil Jouvenat II (University of Nebraska Medical Center/Nebraska Medicine)	No disclosure on file
	No disclosure on file

��ɫ��

��ɫ��