Abstract Details

Title Validation of a New Portable (Goggles) Technique for Determination of the Visual Temporal Discrimination Threshold

Topic Movement Disorders

Presentation(s) P07 - (-)

Poster/Presentation
Number 198

Objective

Background BACKGROUND: The visual temporal discrimination threshold (TDT) test determines the temporal threshold at which two LED lights, positioned on a table in front of the subject and flashing at variable intervals, appear to be asynchronous in onset. We have demonstrated that the TDT is a sensitive endophenotype in adult onset primary torsion dystonia (AOPTD) patients and unaffected first-degree relatives. The test has been limited to the laboratory setting due to the need for a darkened environment.

Design/Methods DESIGN/METHODS: The visual goggles TDT system is a head mounted device made of laser-sintered nylon plastic with high strength, low transparency rating, incorporating a mirror reflection system. LEDs are placed left and right of a central crosshair point, ensuring that the dimensions of 700mm and 7 degrees of the traditional method are preserved. The mirrors reflect the LEDs that are positioned at the rear of the device, providing a focal length of 350mm. We compared TDTs determined by both goggles and traditional techniques in healthy control participants.

Results RESULTS: In 15 healthy control participants examined by both the traditional and portable methods to date there were no significant differences in mean visual TDT scores.

Conclusions CONCLUSIONS: This novel portable device for TDT acquisition will facilitate acquisition of TDT data in a larger cohort of AOPTD patients and relatives in their homes in order to identify potential gene carriers among families of affected patients for genetic studies.

Authors/Disclosures
Anna M. Whelehan, MD PRESENTER	No disclosure on file
Okka T. Kimmich, MD (DZNE German Centre for Neurodegenerative Diseases)	No disclosure on file
	No disclosure on file
	No disclosure on file
Yuval Dadon, MD	No disclosure on file
	No disclosure on file
Sean O'Riordan, MD (St. Vincent's University Hosp)	Dr. O'Riordan has nothing to disclose.
Michael Hutchinson, MD (St Vincent's University Hospital)	Dr. Hutchinson has nothing to disclose.
	No disclosure on file

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