Abstract Details

Title Association of Slow Reaction Time with Future Risk of Parkinson's Disease in the Honolulu-Asia Aging Study

Topic Movement Disorders

Presentation(s) P03 - (-)

Poster/Presentation
Number 063

Objective

Background BACKGROUND: Reaction time (RT) is known to be slow in PD patients. However, it is not known whether slow RT may be a predictor of incident PD.

Design/Methods DESIGN/METHODS: During the 1994-96 examination of the population based, longitudinal Honolulu-Asia Aging Study, 2,705 men, aged 74 to 95 years and free of PD, were administered simple RT (SRT) and choice RT (CRT) tests performed with a laptop computer. Subjects were divided into quartiles of reaction time. Diagnosis of incident PD over 7 years of follow-up was made according to published criteria. Separate analyses were performed for SRT and CRT, using the fastest quartile of each as reference.

Results RESULTS: There were 25 cases of incident PD during follow-up. Incidence increased from 5.7, to 20.0, to 19.1, to 25.0 per 10,000 person-years from the fastest to slowest quartiles respectively (P for trend=0.03). Using multivariate Cox regression, adjusting for age, education, baseline cognitive test score, prevalent stroke, handedness, handgrip strength, percent SRT error rate and amount of caffeine intake, men in the slowest quartile of SRT were significantly more likely to develop incident PD compared to those in the fastest quartile (RR=5.32, 95% CI=1.05-26.9, p=0.04). Analyses were repeated on men who were cognitively intact at baseline and without prevalent stroke, and those in the slowest quartile of SRT still had higher risk of PD (RR=5.03, 95% CI=0.96-26.2, p=0.055). There was no significant association between CRT and incident PD.

Conclusions CONCLUSIONS: Men in the slowest quartile of SRT were significantly more likely to develop incident PD compared to those in the fastest quartile. Measurement of SRT is a low cost screening method that may help to identify those at risk for PD in later life.

Authors/Disclosures
Web Ross, MD (Pacific Health Research and ��ɫ�� Institute) PRESENTER	The institution of Dr. Ross has received research support from Michael J Fox Foundation. The institution of Dr. Ross has received research support from NIH.
Tim Sinnecker	No disclosure on file
	No disclosure on file
Kamal Masaki, MD	No disclosure on file
Robert D. Abbott, PhD (University of Virginia School of Medicine)	No disclosure on file
	No disclosure on file
Christina Bell	No disclosure on file
Helen Petrovitch, MD (Pacific Health Research Institute)	No disclosure on file
Caroline M. Tanner, MD, PhD, FAAN (University of California San Francisco, Weill Institute for Neurosciences)	Dr. Tanner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Evidera. Dr. Tanner has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Neurocrine. Dr. Tanner has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jazz Pharmaceuticals/Cavion. Dr. Tanner has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bial . Dr. Tanner has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Supernus. Dr. Tanner has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche Genentech. The institution of Dr. Tanner has received research support from Gateway LLC. The institution of Dr. Tanner has received research support from Roche\Genentech. The institution of Dr. Tanner has received research support from Michael J Fox Foundation . The institution of Dr. Tanner has received research support from National Institute of Health . The institution of Dr. Tanner has received research support from Department of Defense. Dr. Tanner has received personal compensation in the range of $500-$4,999 for serving as a Faculty, CME presentation with Medscape /WebND.
Lenore J. Launer, PhD (National Institute on Aging)	No disclosure on file
Lon R. White, MD	No disclosure on file

��ɫ����

��ɫ����

��ɫ��

��ɫ��