Abstract Details

Title Post-Stroke Aphasia: Differences in White Matter Fractional Anisotropy between Recovered and Non-Recovered Patients

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P03 - (-)

Poster/Presentation
Number 161

Objective

Background BACKGROUND: LMCA stroke often results in language deficits in addition to damage in left hemispheric regions and their connections. Diffusion tensor imaging (DTI) allows examination of differences in white matter fractional anisotropy (FA) between individuals who recovered language function ?1 year following LMCA stroke and those who remained aphasic.

Design/Methods DESIGN/METHODS: 27 LMCA stroke subjects ?1 year post-stroke underwent anatomical T1-weighted MRI and 32-direction DTI. Language ability was categorized based on their Token Test performance: 9 scored in the normal range (?41); 18 were considered aphasic (<41). Images were pre-processed in AFNI including co-registration of anatomical and DTI scans, motion and eddy current distortion correction, and tensor decomposition to create individual subject FA maps. Tract-Based Spatial Statistics (TBSS) method in FSL was used to prepare subject FA maps for group analysis. FA threshold was set to ?0.3 to restrict analysis to white matter. Two-sample t-test was performed to compare white matter FA of patients with and without aphasia; Threshold Free Cluster Enhancement (TFCE) method was used to correct for multiple comparisons.

Results RESULTS: We observed overall greater FA in the left hemisphere white matter of non-aphasic patients compared to aphasic patients (corrected p<0.05), including in the corticospinal tract, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, internal capsule, superior longitudinal fasciculus and the forceps minor. Increased FA in non-aphasic compared to aphasic patients was also widespread in the corpus callosum (corrected p<0.05).

Conclusions CONCLUSIONS: Greater left hemispheric damage to brain structures and decreased intrahemispheric connections in patients with aphasia are evident in the white matter FA differences between the groups. Group differences in corpus callosum FA also indicate possible reductions in interhemispheric connections in chronically aphasic patients. These group differences may underlie post-stroke recovery.

Authors/Disclosures
Jane B. Allendorfer, PhD (U of Alabama At Birmingham, Neurology) PRESENTER	The institution of Dr. Allendorfer has received research support from National Institutes of Health. The institution of Dr. Allendorfer has received research support from Evelyn F. McKnight Brain Institute. The institution of Dr. Allendorfer has received research support from LivaNova, Inc. Dr. Allendorfer has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Cleveland Clinic. Dr. Allendorfer has received personal compensation in the range of $0-$499 for serving as a Examiner with University of Auckland. Dr. Allendorfer has received personal compensation in the range of $500-$4,999 for serving as a Speaker with International League Against Epilepsy. Dr. Allendorfer has received personal compensation in the range of $500-$4,999 for serving as a Grant Reviewer with Department of Defense. Dr. Allendorfer has a non-compensated relationship as a Scientific Program Committee Member with American Epilepsy Society that is relevant to AAN interests or activities. Dr. Allendorfer has a non-compensated relationship as a Editorial Board Member with Epilepsy and Behavior Reports that is relevant to AAN interests or activities.
Jerzy P. Szaflarski, MD, PhD, FAAN (University of Alabama At Birmingham)	Dr. Szaflarski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB Pharma. Dr. Szaflarski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for LivaNova Inc. Dr. Szaflarski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for PureTech Health. Dr. Szaflarski has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Gidley, Sarli & Marusak, LLP. Dr. Szaflarski has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Szaflarski has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Law Firm. Dr. Szaflarski has stock in AdCel Biopharma, LLC. Dr. Szaflarski has stock in iFovea.
Basil T. Darras, MD (Children'S Hosp Boston Harvard Med School)	The institution of Dr. Darras has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amicus. Dr. Darras has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Amicus. The institution of Dr. Darras has received research support from National Institutes of Health/National Institute of Neurological Disorders and Stroke,. The institution of Dr. Darras has received research support from Slaney Family Fund for SMA. The institution of Dr. Darras has received research support from Spinal Muscular Atrophy Foundation. The institution of Dr. Darras has received research support from CureSMA. The institution of Dr. Darras has received research support from Working on Walking Fund . The institution of Dr. Darras has received research support from CHERISH, CS2/CS12 . The institution of Dr. Darras has received research support from Biogen for CS11. The institution of Dr. Darras has received research support from AveXis. The institution of Dr. Darras has received research support from Sarepta Pharmaceuticals. The institution of Dr. Darras has received research support from PTC Therapeutics. The institution of Dr. Darras has received research support from Roche. The institution of Dr. Darras has received research support from Santhera. The institution of Dr. Darras has received research support from Scholar Rock. The institution of Dr. Darras has received research support from Fibrogen. The institution of Dr. Darras has received research support from Summit. Dr. Darras has received publishing royalties from a publication relating to health care. Dr. Darras has received publishing royalties from a publication relating to health care.

��ɫ��

��ɫ��