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Abstract Details

Social Dysfunction in Patients with Behavioral Variant Frontotemporal Dementia and Early-Onset Alzheimer's Disease
Behavioral Neurology
P05 - (-)
112
BACKGROUND: Declines in social functioning are a characteristic feature of bvFTD, whereas social functioning in EOAD patients remains relatively intact. We compared the two groups' scores on the Social Dysfunction Scale (SDS), and we used tensor-based morphometry (TBM) to map the association between SDS scores and regional brain volumes.
DESIGN/METHODS: 19 participants (mean age=60.0, sd=7.9), including 9 with bvFTD and 10 with EOAD, underwent MRI and clinical assessment. The bvFTD and EOAD subjects did not differ on any demographic characteristics. SDS scores were compared using an independent-samples t-test, and TBM was applied to 3D T1-weighted MRI scans. Each individual image was warped to a common brain template, and Jacobian maps showing the expansion or compression factor at each voxel were created. Mean Jacobian values within selected regions of interest were computed for each subject to provide a numeric summary of regional volume. Voxel-wise regression was performed on the Jacobian maps.
RESULTS: bvFTD subjects (mean SDS=145.78, sd=27.15) scored significantly higher than EOAD patients (mean SDS=78.10, sd=27.47) on the SDS (t=5.39, p<.001). In the overall sample, SDS scores were not significantly correlated with frontal (r=-.32, p=.18), temporal (r=.30, p=.22), or parietal (r=.12, p=.63) lobe volume. A more regionally specific analysis of the orbitofrontal cortex and anterior temporal lobe revealed that SDS scores were significantly associated with orbitofrontal volume (r=-.63, p=.004), but not anterior temporal volume (r=-.19, p=.45). Within-group correlations were non-significant, but were in the same general direction (FTD: r=-.23, p=.54; AD: r=-.33, p=.35).
CONCLUSIONS: bvFTD subjects demonstrated more social dysfunction than EOAD subjects. Impaired social functioning in bvFTD and EOAD, as assessed by the SDS, appears to be associated specifically with orbitofrontal volume, but not with anterior temporal, parietal or overall frontal volume.
Authors/Disclosures
Stephanie Melchor
PRESENTER 		No disclosure on file
Gerhard Winkler, MD No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Natalie Kaiser (West Los Angeles VA Medical Center) No disclosure on file
No disclosure on file
Paul M. Thompson, PhD (USC) No disclosure on file
Mario F. Mendez, MD, PhD, FAAN (VA Greater Los Angeles Healthcare System and UCLA) Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medical 好色先生 Speakers' Bureau. Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for UpToDate. The institution of Dr. Mendez has received research support from NIH. Dr. Mendez has received publishing royalties from a publication relating to health care.