Abstract Details

Title Vitamin D Levels in African-Americans and Caucasian with Relapsing Multiple Sclerosis: Relationship with Disease Course

Topic MS and Related Diseases

Presentation(s) P05 - (-)

Poster/Presentation
Number 135

Objective

Background BACKGROUND: Vitamin D, a secosteroid, may favorably affect disease course in MS. Additionally, vitamin D metabolism and serum levels are affected by multiple factors including diet and exposure to sunlight. It is well-known that AA-MS patients experience a more aggressive disease course than CA-MS. We investigated the relationship between vitamin D and disease course in AA-MS compared to CA-MS.

Design/Methods DESIGN/METHODS: This was a cross-sectional study design. Records were obtained from our MS Center with well-characterized MS patients. Only relapsing MS patients (RR or SP) were included. Moreover, only those patients were included who were not taking or had not previously received vitamin D supplements at the time of measurement of vitamin D levels.

Results RESULTS: 100 consecutive patients in the AA-MS and CA-MS groups each, were included in the study. Mean age, disease duration, and time to onset of Rx were similar in the groups. However, mean EDSS were 4.3 (2.0) in the AA-MS and 3.1 (1.9) in the CA-MS (p<0.0001) and mean T2LL were 18.12 (11.08) ml and 13.32 (8.01) ml (p<0.0001) in the AA-MS and CA-MS, respectively. Mean vitamin D levels were 16.6 (6.8) in the AA-MS and 23.7 (8.6) ng/ml in the CA-MS patients (p<0.0001). Vitamin D levels showed significant inverse correlation with EDSS and T2LL in both patient groups. Additional analyses with multiple regression will also be presented.

Conclusions CONCLUSIONS: AA-MS patients demonstrate significantly lower and deficient vitamin D levels compared to CA-MS patients. Low vitamin D level is associated with higher disability and MRI disease burden disease in both groups. Lower vitamin D levels in AA-MS may partly contribute to a worse outcome, well-described in this population with MS.

Authors/Disclosures
Akram H. Dastagir, MD (Minneapolis Clinic of Neurology) PRESENTER	No disclosure on file
Abdulradha Alqallaf, MD (Amiri Hospital)	Dr. Alqallaf has nothing to disclose.
Fen Bao	Fen Bao has nothing to disclose.
Srilatha Thadur, MD	No disclosure on file
Sabeen Lulu, MD	No disclosure on file
Evanthia Bernitsas, MD, FAAN (Wayne State School of Medicine)	Dr. Bernitsas has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amgen. Dr. Bernitsas has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Vanda. The institution of Dr. Bernitsas has received research support from Roche/Genentech.
Christina Caon, RN, BS (38 North Street)	Ms. Caon has received personal compensation for serving as an employee of EMD Serono.
Omar A. Khan, MD, PhD (Dept of Neuro/Wayne State Univ Sch of Med)	No disclosure on file
Giancarlo Comi, MD (University Vita-Salute)	Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.

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