Abstract Details

Title Factors Affecting Proportion of Supine Sleep in Patients Referred for Obstructive Sleep Apnea Evaluation: Focusing on Severity of Obstruction during Supine Sleep

Topic Sleep

Presentation(s) P05 - (-)

Poster/Presentation
Number 016

Objective

Background BACKGROUND: Sleep position affetcs the severity of sleep apnea. Not enough information is known about factors that affect supine sleep. Knowing the factors that affect position of sleep will help come up with effective way of treating OSA with positional therapy.

Design/Methods DESIGN/METHODS: Retrospective review of diagnostic polysomnograms of 200 adult subjects who were referred to University of Iowa sleep lab for evaluation of OSA was undertaken after IRB approval. Biometric parameters and sleep study parameters were analyzed as potential factors affecting the proportion of supine sleep out of total sleep time.

Results RESULTS: Patients without OSA spent 50 % of sleep time supine and patients with OSA spent 44% of sleep time supine. In non-OSA subjects, age was inversely correlated to supine sleep (p<0.05). Neck circumference showed inverse relation in OSA patient with p<0.05 but not in non-OSA subjects. BMI had no correlation with supine sleep in neither OSA nor non-OSA group. Supine AHI(p<0.0001) and non-supine AHI(p<0.05) showed inverse relation. The difference between supine-AHI and non-supine-AHI(p<0.0001) showed strongest inverse correlation. NREM sup-AHI showed statistically significant(<0.0001) inverse relationship to supine sleep compared to rem-sup AHI(>0.05). NREM non-supine AHI showed statistically significant(<0.001) inverse relation compared REM non-supine AHI(>0.05).

Conclusions CONCLUSIONS: Older aged was associated with less supine sleep only in subjects without OSA. In patients with OSA, biger the neck circumference, less sleep they spent in supine position. The strongest factor in determining the amount of supine sleep proportion in OSA was the difference between supine-AHI and non-supine AHI. In other words, the greater the benefit in reduction of AHI from sleeping non-supine, the more the patient slept non-supine.

Authors/Disclosures
PRESENTER	No disclosure on file
Gary R. Cutter, PhD (University of Alabama At Birmingham)	Dr. Cutter has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for onsulting or Advisory Boards: Alexion, Antisense Therapeutics/Percheron, Avotres, Biogen, Clene Nanomedicine, Clinical Trial Solutions LLC, Endra Life Sciences, Cognito Therapeutics, Genzyme, Genentech, Immunic, Klein-Buendel Incorporated, Kyverna Therapeutics, Inc. , Linical, Merck/Serono, Noema, Neurogenesis, Perception Neurosciences, Protalix Biotherapeutics, Regeneron, Revelstone Consulting, Roche, SAB Biotherapeutics, Sapience Therapeutics, Scott&Scott LLP, Tenmile.. Dr. Cutter has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Data and Safety Monitoring Boards: Applied Therapeutics, AI therapeutics, AMO Pharma, Argenx, Astra-Zeneca, Avexis Pharmaceuticals, Bristol Meyers Squibb, CSL Behring, Cynata Therapeutics, DiamedicaTherapeutics, Horizon Pharmaceuticals, Immunic, Inhibrix, Karuna Therapeutics, Kezar Life Sciences, Medtronic, Merck, Meiji Seika Pharma, Mitsubishi Tanabe Pharma Holdings, Prothena Biosciences, Novartis, Pipeline Therapeutics (Contineum), Regeneron, Sanofi-Aventis, Teva Pharmaceuticals, United BioSource LLC, University of Texas Southwestern.. Dr. Cutter has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JASN.
	No disclosure on file
Atif Zafar, MD (St. Michael's Hospital (University of Toronto))	Dr. Zafar has nothing to disclose.
Kyoungbin Im (University of Iowa)	No disclosure on file

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