Abstract Details

Title The Prevalence of Incidental Findings on Magnetic Resonance Imaging Studies in Multiple Sclerosis Patients

Topic MS and Related Diseases

Presentation(s) P03 - (-)

Poster/Presentation
Number 210

Objective

Background BACKGROUND: The issue of reporting and managing incidental findings has important implications for patient safety; is integral to the informed consent process in clinical research. Magnetic resonance imaging (MRI) is widespread in multiple sclerosis (MS) studies, yet the prevalence rate of incidental findings in MS is unknown.

Design/Methods DESIGN/METHODS: This was a cross sectional study of 120 MS patients and 60 age and sex-matched controls. During the consent process, patients were informed that they would be made aware of incidental findings by the principal investigator.

Results RESULTS: The MS subgroup (mean age 45. 8 years; 74 males) included 89 relapsing remitting, 12 primary progressive, 15 secondary progressive, 3 clinically isolated syndrome, and 1 Neuromyelitis Optica patient. The median Expanded Disability Status Scale score was 3.0 (0 - 7.5) and the mean disease duration was 12.9 years (range 1 - 40 years). To date, 23 subjects were found to have incidental abnormalities detected on study brain and neck MRI, including: thyroid nodules (6 controls, 4 MS patients), pituitary lesions (1 control, 1 MS patient), a subclinical stroke (1 control), cavernomas (2 controls, 3 MS patient), enlarged cervical lymph nodes (1 MS patient), a disc protrusion (1 MS patient), a thoracic spinal meningioma (1 control), and 2 aneurysms (2 MS patients). All subjects were made aware of significant findings by the principal investigator, with appropriate management initiated.

Conclusions CONCLUSIONS: Given the frequency of MRI brain incidental abnormalities in our study cohort amongst our study participants, we suspect such findings are common. Improved patient enrolment and relationships are likely to stem from a transparent approach to these unexpected results.

Authors/Disclosures
PRESENTER	No disclosure on file
LECIO FIGUEIRA PINTO, MD (Hospital Das Clinicas Sao Paulo)	No disclosure on file
Fiona E. Costello, MD (Fiona Costello Professional Corporation)	Dr. Costello has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. Dr. Costello has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Costello has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Costello has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Alexion. Dr. Costello has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Accure Therapeutics. Dr. Costello has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for the Sumaira Foundation.
Michael D. Hill, MD (University of Calgary)	Dr. Hill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boehringer Ingelheim. Dr. Hill has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sun Pharma. Dr. Hill has received stock or an ownership interest from Circle Neurovascular.
Jodie Burton, MD, FAAN	Dr. Burton has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche. Dr. Burton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Burton has received personal compensation in the range of $0-$499 for serving as a Consultant for Horizon. The institution of Dr. Burton has received research support from Roy and Joan Allen Professorship for Sight. Dr. Burton has a non-compensated relationship as a Advisor with CADTH that is relevant to AAN interests or activities. Dr. Burton has a non-compensated relationship as a Advisor with Alexion that is relevant to AAN interests or activities. Dr. Burton has a non-compensated relationship as a Advisor with Horizon that is relevant to AAN interests or activities. Dr. Burton has a non-compensated relationship as a ��ɫ��al Chair with EMD Serono that is relevant to AAN interests or activities.
	No disclosure on file
Jean K. Mah, MD, FRCPC, FAAN (University of Calgary)	Dr. Mah has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
James N. Scott, MD	No disclosure on file

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