Abstract Details

Title A Novel System To Evaluate the Dynamic Cerebellar Motor Learning Capability and Its Application Identifies a Clinical Marker in Cerebellar Ataxias

Topic Movement Disorders

Presentation(s) P02 - (-)

Poster/Presentation
Number 078

Objective

Background BACKGROUND: The human cerebellum has essential roles not only in maintaining balance and coordination, but also in motor learning also called adaptation. We focused on the motor learning capability which is governed by the neural circuitries involving the brainstem and the cerebellum.

Design/Methods DESIGN/METHODS: We developed a novel system which employs a prism lens task that induces cerebellar motor learning (Martin et al. Brain, 1996) in conjunction with a specially equipped touch-panel screen. Wearing the prism lens makes the examinee see a false target shifted toward the direction of the lens. When the examinee touches a false target, the screen detects the distance from the true target to the touched point. This simultaneously allows the examinee to recognize the deviation which triggers the cerebellar motor learning involving the long-term depressions (LTD) at the cerebellar cortex. In the subsequent trials, the examinee gradually learns to minimize the deviations even the true target moves on the screen in every trial. Removing the prism lens from the examinee's sights induces another motor learning, because one has adapted from the prior optically false condition. We investigated both normal (n=22) and ataxic subjects (n=12) with this system.

Results RESULTS: We found an objective criterion evaluating the motor learning competency, in which normal individuals showed values between 0.5 and the maximum value of 1, whereas individuals with cerebellar degenerations such as spinocerebellar ataxia type 6 (SCA6) or SCA31 showed less than 0.4. Individuals showing ataxic hemiparesis due to a thalamic lesion with multiple sclerosis or whom showing sensory ataxia showed normal values.

Conclusions CONCLUSIONS: We conclude that the present system could be a powerful tool to evaluate cerebellar functions, and it could be also used for the differential diagnosis of ataxic symptoms.

Authors/Disclosures
PRESENTER	No disclosure on file
Kinya Ishikawa, MD, PhD (Tokyo Med & Dental Univ)	Dr. Ishikawa has nothing to disclose.
	No disclosure on file
Noah Rosen, MD, FAAN	Dr. Rosen has received personal compensation for serving as an employee of Northwell Health. An immediate family member of Dr. Rosen has received personal compensation for serving as an employee of New York University. Dr. Rosen has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Allergan/ Abbvie. Dr. Rosen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lundbeck. Dr. Rosen has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Pfizer . Dr. Rosen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amneal. Dr. Rosen has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Allergan/ Abbvie. Dr. Rosen has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Pfizer. Dr. Rosen has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer.
	No disclosure on file
Hidehiro Mizusawa, MD, PhD (National Center of Neurology and Psychiatry)	No disclosure on file

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