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Abstract Details

CSF Total and Phosphorylated Tau Biomarker Findings in a Large Rapidly Progressive Dementia Cohort
Aging and Dementia
P03 - (-)
077
BACKGROUND: TTau has been reported as a reliable diagnostic maker for differentiating CJD from npRPD patients, but its utility is still not clear. We examined CSF levels for TTau alone compared to the ratio of TTau/PTau.
DESIGN/METHODS: Data from medical records was stored in a secure database and queried. Most subjects, including npRPD, were referred as suspected CJD. sCJD patients either were pathology-proven or met UCSF or WHO criteria for probable CJD. Non-prion diagnoses were based on published, or accepted, criteria. Only the first LP in which both biomarkers were assessed was used for subjects with multiple lumbar punctures.
RESULTS: TTau and TTau/PTau was evaluated in 55 sCJD and 36 npRPD subjects. Using previously published TTau cut-off point (positive at >1200 pg/mL), the sensitivity was 58% and the specificity 92%. The sensitivity and specificity of TTau/PTau cutoffs of 15, 20, and 25 were 87% and 81%, 76% and 89%, and 65% and 92%, respectively.
CONCLUSIONS: Our data suggest that a CSF TTau/PTau ratio ? 25 might be a better diagnostic marker than TTau alone at >1200 pg/mL.
Authors/Disclosures
Sven Forner
PRESENTER 		No disclosure on file
Laurence Mignon, PhD (Ionis Pharmaceuticals, Inc) No disclosure on file
Kendra Bechtel No disclosure on file
Katherine Wong, MD (University of Southern California) Dr. Wong has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for various law firms. Dr. Wong has stock in Biogen.
Michael D. Geschwind, MD, PhD, FAAN (UCSF) Dr. Geschwind has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Brainstorm Cell Therapeutics, Inc.. Dr. Geschwind has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Walter Grubb. Dr. Geschwind has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Gerson Lehrman Group. Dr. Geschwind has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Reata Pharmaceuticals, Inc..