Abstract Details

Title Increased Hemoglobin A1c Level Is Associated with Decreased Hematoma Volume in Patients with Spontaneous Intracerebral Hemorrhage

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P03 - (-)

Poster/Presentation
Number 176

Objective

Background BACKGROUND: Diabetic and non-diabetic patients with hyperglycemia, are associated with poorer outcome after spontaneous intracerebral hemorrhage (ICH). Hyperglycemia in acute stroke has been considered a manifestation of premorbid diabetic glucose metabolism.

Design/Methods DESIGN/METHODS: We conducted a retrospective analysis of ICH patients admitted to Neuro-ICU between July 2009 and June 2012 at a community teaching hospital. Initialhead CT was used to calculate (BHV). Initial HbA1c levels were obtained. Patients were divided into three HbA1c groups as follows: (1) < 6, (2) 6-6.5, (3) > 6.5. BHV was compared to HbA1c levels and means were computed between groups. Initial glucose levels were compared to ICH score, BHV, and mRS. Statistical analysis was conducted using SPSS software version 20.

Results RESULTS: The study included 232 patients (mean age = 68.30 +/- 14.7, 59% male). Mean HbA1c and BHV levels were as follows: (1) 5.57, 21.084 ml (N=100), (2) 6.15, 19.0937 ml (N=61), (3) 7.81, 15.6554 ml (N=71), respectively. HbA1c negatively correlated with BHV (r = -0.232, p < 0.05). There was a statistically significant difference for BHV in respect to HbA1c between (1) and (3) (p < 0.05). There was no statistically significant difference for ICH score and mRS in respect to HbA1c groups. Patients in (1) with higher glucose levels had higher ICH score , BHV, and mRS (p < .001).

Conclusions CONCLUSIONS: Our data showed inverse correlation between HbA1c levels and BHV. This contradiction may suggest that acute hyperglycemia in response to acute stress is the effect rather than cause of severe ICH. Further studies to determine if increased HbA1c levels lead to the early activation of clotting factors in ICH patients, or increased HbA1c levels lead to changes in the structure of the vessel wall is warranted.

Authors/Disclosures
Siddhart K. Mehta, MD PRESENTER	Dr. Mehta has nothing to disclose.
Punam Dass, MD (Mount Sinai)	Dr. Dass has nothing to disclose.
Mohammad Moussavi, MD	Dr. Moussavi has nothing to disclose.
Brian Kopell	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Haitham Dababneh, MD	No disclosure on file
	No disclosure on file
Jawad F. Kirmani, MD	Dr. Kirmani has nothing to disclose.

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