Abstract Details

Title The Prevalence of Stroke in Parkinson's Disease Is High: A Risk Factor Assessment

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) (-)

Poster/Presentation
Number 003

Objective

Background Several studies have documented a low risk of stroke in previously diagnosed Parkinson's disease patients, but no studies have been done to specifically assess stroke risk factors in these patient population.

Design/Methods We conducted a case-control retrospective study, 820 consecutive medical records of patients with iPD were reviewed from the Movement Disorder Center at the Cleveland Clinic Florida from January 2005 to December 2010. Patients with atypical PD or previous history of atrial fibrillation were excluded. Thirty four patients with iPD were identified to have suffered an ischemic stroke or transient ischemic attack (TIA). These patients were compared with the iPD patients without stroke or TIA.

Results The study population was composed of 820 patients: 786 controls and 34 cases. The calculated prevalence of stroke in IPD patients was 4.15%. The mean age was 75 (SD=13) in the controls and 72.7 (SD=11.1) in the cases. Hyperlipidemia (OR 4.1; 95%, CI 1.97 to 8.58) and diabetes (OR 2.6; 95% CI, 1.18-5.70) were significantly associated with increased risk of stroke in the iPD/stroke-TIA group. High doses of levodopa (OR 2.2; 95% CI, 1.09 to 4.41), antiplatelet therapy (OR 2.0; 95% CI, 1.00 to 3.97) and statins (OR 2.0; 955 CI 1.025 to 4.07) were also associated with a higher risk of stroke.

Conclusions The prevalence of stroke in iPD was found to be higher than in the general population. We found a 3 and 4 fold increased risk of having stroke or TIA in iPD patients with diabetes and hyperlipidemia, respectively. In addition, antiplatelet medications and high dose of levodopa were found to have a 2 fold increased risk of having a stroke in iPD patients.

Authors/Disclosures
Camilo I. Garcia-Gracia, MD PRESENTER	Dr. Garcia-Gracia has received personal compensation for serving as an employee of jazz pharmaceutical. Dr. Garcia-Gracia has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Jazz pharmaceutical.
Amy L. Phillips, PharmD (EMD Serono)	Amy L. Phillips, PharmD has received personal compensation for serving as an employee of EMD Serono, Inc.
Tarannum Khan, MD, MBBS, FAAN (Cleveland Clinic)	Dr. Khan has nothing to disclose.
Dennys Reyes, MD (Reyes Neurology)	No disclosure on file
Shira McMahan, DO	No disclosure on file
Nestor Galvez-Jimenez, MD (Cleveland Clinic - Florida)	Dr. Galvez-Jimenez has nothing to disclose.

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