Abstract Details

Title Depression Is the Major Determinant of Fatigue in SCA3

Topic Movement Disorders

Presentation(s) (-)

Poster/Presentation
Number 002

Objective

Background Fatigue is one of the most disabling non-motor features in spinocerebellar ataxias, including SCA3. Despite this, relevant data about SCA3-related fatigue such as frequency, clinical impact and determinants are still not available.

Design/Methods Forty eight patients with molecular confirmation of SCA3 and 38 healthy age and sex-matched controls answered the Modified Fatigue Impact Scale (MFIS), Beck Inventory Depression (BDI) and Epworth Sleepiness Scale (ESS). MFIS and BDI scores were considered abnormal if ? 5, 38 and 11, respectively. Scale for the assessment and rating of ataxia (SARA) was used to determine the ataxia severity. We used Mann-Whitney and Fisher exact tests to compare mean scores and proportions between groups. Linear regression analyses were employed to investigate determinants of fatigue in SCA3.

Results Mean age of patients and disease duration were 47.0 ± 14.0 and 10.8 ± 7.36 years, respectively. There were 21 men and 27 women. Mean (CAG)n was 72.1 ± 4.8. Mean MFIS score was higher in SCA3 patients (42.8 ± 10.8 vs 18.0 ±13.0, p< 0.001).The proportion of individuals with fatigue was higher among patients (68% vs 5%, p<0.001). We also found higher BDI scores among patients with SCA3 (17.3±10.8 vs 4.7±4.2, p<0.001). In the multiple regression analysis, BDI scores were the only variable associated to fatigue (r=0.63, p<0.001). ESS scores seemed to be related to fatigue, but fell short of reaching statistical significance (p = 0.058).

Conclusions Fatigue is frequent and strongly associated to depression in SCA3, so that it should be actively investigated and promptly treated in these patients.

Authors/Disclosures
Alberto R. Martinez, MD PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Anelyssa D'Abreu, MD, PhD, MPH, FAAN (Department of Neurology- University of Virginia)	The institution of Dr. D'Abreu has received research support from U.S. NIH Institute on Aging. The institution of Dr. D'Abreu has received research support from Biogen. The institution of Dr. D'Abreu has received research support from American College Of Radiology. The institution of Dr. D'Abreu has received research support from COGNITION THERAPEUTICS, INC.. The institution of Dr. D'Abreu has received research support from Eli Lilly. The institution of Dr. D'Abreu has received research support from Jansen. Dr. D'Abreu has received personal compensation in the range of $10,000-$49,999 for serving as a Lecturer with Pri_med.
Iscia Lopes-Cendes, MD, PhD (University of Campinas - UNICAMP)	No disclosure on file
Jacqueline Montes, PT, EdD, NCS (Columbia University Medical Center)	Ms. Montes has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Ms. Montes has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for F. Hoffman LaRoche. Ms. Montes has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Scholar Rock. Ms. Montes has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sarepta. The institution of Ms. Montes has received research support from NIH/NICHD. The institution of Ms. Montes has received research support from Muscular Dystrophy Association. The institution of Ms. Montes has received research support from Cure SMA.
	No disclosure on file

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